Peringatan Keamanan

Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.

Ademetionine

DB00118

small molecule approved investigational nutraceutical

Deskripsi

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

Struktur Molekul 2D

Berat 398.44
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.

Metabolisme

Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

29 Data
Enflurane The metabolism of Enflurane can be decreased when combined with Ademetionine.
Trimethadione The metabolism of Trimethadione can be decreased when combined with Ademetionine.
Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Ademetionine.
Isoflurane The metabolism of Isoflurane can be decreased when combined with Ademetionine.
Ethanol The metabolism of Ethanol can be decreased when combined with Ademetionine.
Methoxyflurane The metabolism of Methoxyflurane can be decreased when combined with Ademetionine.
Halothane The metabolism of Halothane can be decreased when combined with Ademetionine.
Sevoflurane The metabolism of Sevoflurane can be decreased when combined with Ademetionine.
Nilvadipine The metabolism of Nilvadipine can be decreased when combined with Ademetionine.
Aniline The metabolism of Aniline can be decreased when combined with Ademetionine.
Benzyl alcohol The metabolism of Benzyl alcohol can be decreased when combined with Ademetionine.
Felbamate The metabolism of Felbamate can be decreased when combined with Ademetionine.
Cenobamate The metabolism of Cenobamate can be decreased when combined with Ademetionine.
Carvedilol The metabolism of Carvedilol can be decreased when combined with Ademetionine.
Phenytoin The metabolism of Phenytoin can be decreased when combined with Ademetionine.
Fingolimod The metabolism of Fingolimod can be decreased when combined with Ademetionine.
Ethosuximide The metabolism of Ethosuximide can be decreased when combined with Ademetionine.
Selumetinib The metabolism of Selumetinib can be decreased when combined with Ademetionine.
Primidone The metabolism of Primidone can be decreased when combined with Ademetionine.
Benzocaine The metabolism of Benzocaine can be decreased when combined with Ademetionine.
Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Ademetionine.
Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Ademetionine.
Trabectedin The metabolism of Trabectedin can be decreased when combined with Ademetionine.
Theophylline The metabolism of Theophylline can be decreased when combined with Ademetionine.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Ademetionine.
Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Ademetionine.
Acetaminophen Ademetionine may increase the hepatotoxic activities of Acetaminophen.
Propacetamol Ademetionine may increase the hepatotoxic activities of Propacetamol.
Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Ademetionine.

Target Protein

Catechol O-methyltransferase COMT
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 CMTR1
Arsenite methyltransferase AS3MT
Glycine N-methyltransferase GNMT
S-adenosylmethionine decarboxylase proenzyme AMD1
S-adenosylmethionine synthase isoform type-2 MAT2A
Cystathionine beta-synthase CBS
S-adenosylmethionine synthase isoform type-1 MAT1A

Referensi & Sumber

Synthesis reference: Takayasu Tsuchida, Fumihiro Yoshinaga, Shinji Okumura, "Method for producing S-adenosylmethionine or methylthioadenosine by yeast." U.S. Patent US3962034, issued November, 1971.
Artikel (PubMed)
  • PMID: 10762063
    Finkelstein JD, Martin JJ: Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9.
  • PMID: 10720211
    Fodinger M, Horl WH, Sunder-Plassmann G: Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol. 2000 Jan-Feb;13(1):20-33.
  • PMID: 16766004
    Roje S: S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry. 2006 Aug;67(15):1686-98.
  • PMID: 16545107
    Loenen WA: S-adenosylmethionine: jack of all trades and master of everything? Biochem Soc Trans. 2006 Apr;34(Pt 2):330-3.
  • PMID: 8647346
    Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, McCann PP: S-Adenosylmethionine and methylation. FASEB J. 1996 Mar;10(4):471-80.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Donamet
  • Sam-Sulfate — Natrol
  • SAMe
  • SAMe Rx-Mood — Nature's Plus

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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