Urofollitropin

DB00094

biotech approved vet_approved

Deskripsi

Urofollitropin is a urinary-derived follicle-stimulating hormone (FSH) that is extracted and purified from human urine samples. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is typically used injected subcutaneously in combination with human chorionic gonadotropin (hCG) to induce ovulation. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Circulation half life of 3-4 hours, elimination half life of 35-40 hours

Volume Distribusi Time to peak in plasma: IM: 17 hours (single dose), 11 hours (multiple doses) SubQ: 21 hours (single dose), 10 hours (multiple doses)

Klirens (Clearance) -

Absorpsi

74%

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Via liver and kidneys

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Follicle-stimulating hormone receptor FSHR

Referensi & Sumber

Artikel (PubMed)

PMID: 18020563
Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60.

Contoh Produk & Brand

Produk: 4 • International brands: 2

Produk

Bravelle

Powder, for solution • 75 unit / vial • Intramuscular; Subcutaneous • Canada • Approved
Fertinorm Hp 150 - Pws Diluent Im Sc

Kit; Liquid; Powder, for solution • - • Intramuscular; Subcutaneous • Canada • Approved
Fertinorm Hp 75 - Pws Diluent Im Sc

Liquid; Powder, for solution • - • Intramuscular; Subcutaneous • Canada • Approved
Metrodin 75 I.U.

Powder, for solution • 75 unit / amp • Intramuscular • Canada • Approved

International Brands

Fertinex — Serono S.A.
Metrodin — Serum Inst.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.