Felypressin

DB00093

biotech experimental

Deskripsi

A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

10 Data

Patent Blue	The risk or severity of hypotension can be increased when Patent Blue is combined with Felypressin.
Thyrotropin alfa	Thyrotropin alfa may increase the vasoconstricting activities of Felypressin.
Liothyronine	Liothyronine may increase the vasoconstricting activities of Felypressin.
Levothyroxine	Levothyroxine may increase the vasoconstricting activities of Felypressin.
Liotrix	Liotrix may increase the vasoconstricting activities of Felypressin.
Tiratricol	Tiratricol may increase the vasoconstricting activities of Felypressin.
Thyroid, porcine	Thyroid, porcine may increase the vasoconstricting activities of Felypressin.
Lidocaine	The risk or severity of hypertension can be increased when Felypressin is combined with Lidocaine.
Oxytocin	The risk or severity of hypertension can be increased when Felypressin is combined with Oxytocin.
Chloroprocaine	The risk or severity of adverse effects can be increased when Felypressin is combined with Chloroprocaine.

Target Protein

Vasopressin V1a receptor AVPR1A

Referensi & Sumber

Synthesis reference: Boissonnas, R.and Guttmann, S.; U.S. Patent 3,232,923; February 1, 1966: assigned to Sandoz AG, Switzerland.

Artikel (PubMed)

PMID: 17177590
Cecanho R, De Luca LA Jr, Ranali J: Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.

Contoh Produk & Brand

Produk: 0 • International brands: 2

International Brands

Colupressine — Joullie
Octapressin — Sandoz

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.