Peringatan Keamanan

While it has been found to cross the placenta in monkeys, it is not yet known if it also diffuses into breast milk.

Alefacept

DB00092

biotech approved investigational withdrawn

Deskripsi

Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) ~270 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bioavailability after IM administration is 63%.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

353 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Alefacept.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Alefacept.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Alefacept.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Alefacept.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Alefacept.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Alefacept.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Alefacept.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Alefacept.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Alefacept.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Alefacept.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Alefacept.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Alefacept.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Alefacept.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Alefacept.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Alefacept.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Alefacept.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Alefacept.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Alefacept.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Alefacept.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Alefacept.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Alefacept.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Alefacept.
Efalizumab The risk or severity of adverse effects can be increased when Alefacept is combined with Efalizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Alefacept is combined with Antithymocyte immunoglobulin (rabbit).
Interferon alfa-2b The risk or severity of adverse effects can be increased when Alefacept is combined with Interferon alfa-2b.
Daclizumab The risk or severity of adverse effects can be increased when Alefacept is combined with Daclizumab.
Phenylalanine The risk or severity of adverse effects can be increased when Alefacept is combined with Phenylalanine.
Flunisolide The risk or severity of adverse effects can be increased when Alefacept is combined with Flunisolide.
Bortezomib The risk or severity of adverse effects can be increased when Alefacept is combined with Bortezomib.
Cladribine Alefacept may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Alefacept is combined with Carmustine.
Amsacrine The risk or severity of adverse effects can be increased when Alefacept is combined with Amsacrine.
Bleomycin The risk or severity of adverse effects can be increased when Alefacept is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Alefacept is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Alefacept is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Alefacept is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Alefacept is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Alefacept is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Alefacept is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Alefacept is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Alefacept is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Alefacept is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Alefacept is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Alefacept is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Alefacept is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Alefacept is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Alefacept is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Alefacept is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Alefacept is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Alefacept is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Alefacept is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Alefacept is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Alefacept is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Alefacept is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Alefacept is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Alefacept is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Alefacept is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Alefacept is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Alefacept is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Alefacept is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Alefacept is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Alefacept is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Alefacept is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Alefacept is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Alefacept is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Alefacept is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Alefacept is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Alefacept is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Alefacept is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Alefacept is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Alefacept is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Alefacept is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Alefacept is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Alefacept is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Alefacept is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Alefacept is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Alefacept is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Alefacept is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Alefacept is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Alefacept is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Alefacept is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Alefacept is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Alefacept is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Alefacept is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Alefacept is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Alefacept is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Alefacept is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Alefacept is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Alefacept is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Alefacept is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Alefacept is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Alefacept is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Alefacept is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Alefacept is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Alefacept is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Alefacept is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Alefacept is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Alefacept is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Alefacept is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Alefacept is combined with Melphalan.

Target Protein

T-cell surface antigen CD2 CD2
Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A
Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16865867
    Koo JY, Bagel J, Sweetser MT, Ticho BS: Alefacept in combination with ultraviolet B phototherapy for the treatment of chronic plaque psoriasis: results from an open-label, multicenter study. J Drugs Dermatol. 2006 Jul-Aug;5(7):623-8.
  • PMID: 16713481
    Krell JM: Use of alefacept and etanercept in 3 patients whose psoriasis failed to respond to etanercept. J Am Acad Dermatol. 2006 Jun;54(6):1099-101.
  • PMID: 16673801
    Parrish CA, Sobera JO, Robbins CM, Cantrell WC, Desmond RA, Elewski BE: Alefacept in the treatment of psoriatic nail disease: a proof of concept study. J Drugs Dermatol. 2006 Apr;5(4):339-40.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Amevive
    Kit • 15 mg/0.5mL • Intramuscular • US • Approved
  • Amevive
    Powder, for solution • 15 mg / 0.5 mL • Intramuscular • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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