Capromab pendetide

DB00089

biotech approved

Deskripsi

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. When linked to pendetide, capromab is used as a chelating agent for the radionuclide Indium In-111 during imaging to evaluate the extent of prostate cancer.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi * 4 ± 2.1 L
Klirens (Clearance) * 42 +/- 22 mL/hr

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production

Rute Eliminasi

Approximately 10% of the administered radioisotope dose is excreted in the urine during the 72 hours following intravenous infusion.

Interaksi Obat

393 Data
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Capromab pendetide.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Capromab pendetide.
Estrone Estrone may increase the thrombogenic activities of Capromab pendetide.
Dienestrol Dienestrol may increase the thrombogenic activities of Capromab pendetide.
Estriol Estriol may increase the thrombogenic activities of Capromab pendetide.
Quinestrol Quinestrol may increase the thrombogenic activities of Capromab pendetide.
Hexestrol Hexestrol may increase the thrombogenic activities of Capromab pendetide.
Tibolone Tibolone may increase the thrombogenic activities of Capromab pendetide.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Capromab pendetide.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Capromab pendetide.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Capromab pendetide.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Capromab pendetide.
Zeranol Zeranol may increase the thrombogenic activities of Capromab pendetide.
Equol Equol may increase the thrombogenic activities of Capromab pendetide.
Promestriene Promestriene may increase the thrombogenic activities of Capromab pendetide.
Methallenestril Methallenestril may increase the thrombogenic activities of Capromab pendetide.
Epimestrol Epimestrol may increase the thrombogenic activities of Capromab pendetide.
Moxestrol Moxestrol may increase the thrombogenic activities of Capromab pendetide.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Capromab pendetide.
Biochanin A Biochanin A may increase the thrombogenic activities of Capromab pendetide.
Formononetin Formononetin may increase the thrombogenic activities of Capromab pendetide.
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Capromab pendetide.
Estradiol Estradiol may increase the thrombogenic activities of Capromab pendetide.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Capromab pendetide.
Mestranol Mestranol may increase the thrombogenic activities of Capromab pendetide.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Capromab pendetide.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Capromab pendetide.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Capromab pendetide.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Capromab pendetide.
Estetrol Estetrol may increase the thrombogenic activities of Capromab pendetide.
Leuprolide Leuprolide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Goserelin Goserelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Gonadorelin Gonadorelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Nafarelin Nafarelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Buserelin Buserelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Histrelin Histrelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Triptorelin Triptorelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Deslorelin Deslorelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Danazol Danazol may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Elagolix Elagolix may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Gestrinone Gestrinone may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Flutamide Flutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Nilutamide Nilutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Bicalutamide Bicalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Enzalutamide Enzalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Apalutamide Apalutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Darolutamide Darolutamide may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Cyproterone acetate Cyproterone acetate may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Chlormadinone Chlormadinone may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Relugolix Relugolix may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Chlormadinone acetate Chlormadinone acetate may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Capromab pendetide.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Capromab pendetide.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Capromab pendetide.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Capromab pendetide.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Capromab pendetide.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Capromab pendetide.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Capromab pendetide.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Capromab pendetide.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Capromab pendetide.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Capromab pendetide.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Capromab pendetide.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Capromab pendetide.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Capromab pendetide.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Capromab pendetide.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Capromab pendetide.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Capromab pendetide.
Efalizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Efalizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Antithymocyte immunoglobulin (rabbit).
Natalizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Natalizumab.
Palivizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Palivizumab.
Daclizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Daclizumab.
Bevacizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Bevacizumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Technetium Tc-99m arcitumomab.
Eculizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Eculizumab.
Panitumumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Panitumumab.
Ranibizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Ranibizumab.
Galiximab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Galiximab.
Pexelizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Pexelizumab.
Afelimomab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Afelimomab.
Epratuzumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Epratuzumab.
Bectumomab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Bectumomab.
Oregovomab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Oregovomab.
IGN311 The risk or severity of adverse effects can be increased when Capromab pendetide is combined with IGN311.
Adecatumumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Adecatumumab.
Labetuzumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Labetuzumab.
Matuzumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Matuzumab.
Fontolizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Fontolizumab.
Bavituximab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Bavituximab.
CR002 The risk or severity of adverse effects can be increased when Capromab pendetide is combined with CR002.
Rozrolimupab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Rozrolimupab.
Girentuximab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Girentuximab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Obiltoxaximab.
XTL-001 The risk or severity of adverse effects can be increased when Capromab pendetide is combined with XTL-001.
NAV 1800 The risk or severity of adverse effects can be increased when Capromab pendetide is combined with NAV 1800.
Briakinumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Briakinumab.
Otelixizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Otelixizumab.
AMG 108 The risk or severity of adverse effects can be increased when Capromab pendetide is combined with AMG 108.
Iratumumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Iratumumab.
Enokizumab The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Enokizumab.

Target Protein

Glutamate carboxypeptidase 2 FOLH1

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • ProstaScint Kit for the Preparation of Indium In 111 Capromab Pendetide
    Kit • 0.5 mg/1mL • Intravenous • US • Approved
International Brands
  • ProstaScint — Cytogen Corp.

Sekuens Gen/Protein (FASTA)

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