Tositumomab

DB00081

biotech approved investigational

Deskripsi

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.8 hours (mammalian reticulocytes, in vitro)
Volume Distribusi -
Klirens (Clearance) * 68.2 mg/hr [patients with NHL]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Most likely removed by opsonization via the reticuloendothelial system when bound to B lymphocytes, or by human antimurine antibody production

Rute Eliminasi

Elimination of Iodine-131 occurs by decay and excretion in the urine.

Interaksi Obat

1471 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Tositumomab.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Tositumomab.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Tositumomab.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Tositumomab.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Tositumomab.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Tositumomab.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Tositumomab.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Tositumomab.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Tositumomab.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Tositumomab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Tositumomab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Tositumomab.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Tositumomab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Tositumomab.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Tositumomab.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Tositumomab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Tositumomab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Tositumomab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Tositumomab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Tositumomab.
Alemtuzumab The risk or severity of adverse effects can be increased when Tositumomab is combined with Alemtuzumab.
Alefacept The risk or severity of adverse effects can be increased when Tositumomab is combined with Alefacept.
Efalizumab The risk or severity of adverse effects can be increased when Tositumomab is combined with Efalizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Tositumomab is combined with Antithymocyte immunoglobulin (rabbit).
Interferon alfa-2b The risk or severity of adverse effects can be increased when Tositumomab is combined with Interferon alfa-2b.
Daclizumab The risk or severity of adverse effects can be increased when Tositumomab is combined with Daclizumab.
Phenylalanine The risk or severity of adverse effects can be increased when Tositumomab is combined with Phenylalanine.
Flunisolide The risk or severity of adverse effects can be increased when Tositumomab is combined with Flunisolide.
Bortezomib The risk or severity of adverse effects can be increased when Tositumomab is combined with Bortezomib.
Cladribine Tositumomab may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Tositumomab is combined with Carmustine.
Amsacrine The risk or severity of adverse effects can be increased when Tositumomab is combined with Amsacrine.
Bleomycin The risk or severity of adverse effects can be increased when Tositumomab is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Tositumomab is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Tositumomab is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Tositumomab is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Tositumomab is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Tositumomab is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Tositumomab is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Tositumomab is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Tositumomab is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Tositumomab is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Tositumomab is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Tositumomab is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Tositumomab is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Tositumomab is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Tositumomab is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Tositumomab is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Tositumomab is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Tositumomab is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Tositumomab is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Tositumomab is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Tositumomab is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Tositumomab is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Tositumomab is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Tositumomab is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Tositumomab is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Tositumomab is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Tositumomab is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Tositumomab is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Tositumomab is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Tositumomab is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Tositumomab is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Tositumomab is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Tositumomab is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Tositumomab is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Tositumomab is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Tositumomab is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Tositumomab is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Tositumomab is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Tositumomab is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Tositumomab is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Tositumomab is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Tositumomab is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Tositumomab is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Tositumomab is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Tositumomab is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Tositumomab is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Tositumomab is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Tositumomab is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Tositumomab is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Tositumomab is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Tositumomab is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Tositumomab is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Tositumomab is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Tositumomab is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Tositumomab is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Tositumomab is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Tositumomab is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Tositumomab is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Tositumomab is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Tositumomab is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Tositumomab is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Tositumomab is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Tositumomab is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Tositumomab is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Tositumomab is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Tositumomab is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Tositumomab is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Tositumomab is combined with Melphalan.

Target Protein

B-lymphocyte antigen CD20 MS4A1
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B

Referensi & Sumber

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Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
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  • Bexxar Dosimetric
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  • Bexxar Therapeutic
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  • Bexxar Therapy
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Sekuens Gen/Protein (FASTA)

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