Muromonab

DB00075

biotech approved investigational

Deskripsi

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.8 hours (mammalian reticulocytes, in vitro)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

670 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Muromonab.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Muromonab.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Muromonab.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Muromonab.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Muromonab.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Muromonab.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Muromonab.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Muromonab.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Muromonab.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Muromonab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Muromonab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Muromonab.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Muromonab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Muromonab.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Muromonab.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Muromonab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Muromonab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Muromonab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Muromonab is combined with Ibritumomab tiuxetan.
Tositumomab The risk or severity of adverse effects can be increased when Muromonab is combined with Tositumomab.
Alemtuzumab The risk or severity of adverse effects can be increased when Muromonab is combined with Alemtuzumab.
Alefacept The risk or severity of adverse effects can be increased when Muromonab is combined with Alefacept.
Efalizumab The risk or severity of adverse effects can be increased when Muromonab is combined with Efalizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Muromonab is combined with Antithymocyte immunoglobulin (rabbit).
Interferon alfa-2b The risk or severity of adverse effects can be increased when Muromonab is combined with Interferon alfa-2b.
Daclizumab The risk or severity of adverse effects can be increased when Muromonab is combined with Daclizumab.
Phenylalanine The risk or severity of adverse effects can be increased when Muromonab is combined with Phenylalanine.
Flunisolide The risk or severity of adverse effects can be increased when Muromonab is combined with Flunisolide.
Bortezomib The risk or severity of adverse effects can be increased when Muromonab is combined with Bortezomib.
Cladribine Muromonab may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Muromonab is combined with Carmustine.
Amsacrine The risk or severity of adverse effects can be increased when Muromonab is combined with Amsacrine.
Bleomycin The risk or severity of adverse effects can be increased when Muromonab is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Muromonab is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Muromonab is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Muromonab is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Muromonab is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Muromonab is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Muromonab is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Muromonab is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Muromonab is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Muromonab is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Muromonab is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Muromonab is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Muromonab is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Muromonab is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Muromonab is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Muromonab is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Muromonab is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Muromonab is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Muromonab is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Muromonab is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Muromonab is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Muromonab is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Muromonab is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Muromonab is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Muromonab is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Muromonab is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Muromonab is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Muromonab is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Muromonab is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Muromonab is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Muromonab is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Muromonab is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Muromonab is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Muromonab is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Muromonab is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Muromonab is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Muromonab is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Muromonab is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Muromonab is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Muromonab is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Muromonab is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Muromonab is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Muromonab is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Muromonab is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Muromonab is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Muromonab is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Muromonab is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Muromonab is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Muromonab is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Muromonab is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Muromonab is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Muromonab is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Muromonab is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Muromonab is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Muromonab is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Muromonab is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Muromonab is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Muromonab is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Muromonab is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Muromonab is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Muromonab is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Muromonab is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Muromonab is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Muromonab is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Muromonab is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Muromonab is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Muromonab is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Muromonab is combined with Melphalan.

Target Protein

T-cell surface glycoprotein CD3 delta chain CD3D
T-cell surface glycoprotein CD3 epsilon chain CD3E
T-cell surface glycoprotein CD3 gamma chain CD3G
T-cell surface glycoprotein CD3 zeta chain CD247
Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 2 • International brands: 1
Produk
  • Okt3
    Injection, solution • 5 mg/5mL • Intravenous • US • Approved
  • Orthoclone Okt 3 Sterile Solution IV 1mg/ml
    Solution • 1 mg / mL • Intravenous • Canada • Approved
International Brands
  • Orthoclone OKT3 — Janssen-Cilag

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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