Basiliximab

DB00074

biotech approved investigational

Deskripsi

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7.2 +/- 3.2 days (adults)
Volume Distribusi * 7.8 ± 5.1 L [Pediatric] * 4.8 ± 2.1 L [Adult]
Klirens (Clearance) * 41 +/- 19 mL/h [Adult patients undergoing first kidney transplantation] * 17 +/- 6 mL/h [pediatric patients undergoing renal transplantation] * 31 +/- 19 mL/h [adolescent patients undergoing renal transplantation]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Most likely removed by opsonization via the reticuloendothelial system when bound to lymphocytes, or by human antimurine antibody production

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

670 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Basiliximab.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Basiliximab.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Basiliximab.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Basiliximab.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Basiliximab.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Basiliximab.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Basiliximab.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Basiliximab.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Basiliximab.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Basiliximab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Basiliximab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Basiliximab.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Basiliximab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Basiliximab.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Basiliximab.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Basiliximab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Basiliximab.
Muromonab The risk or severity of adverse effects can be increased when Basiliximab is combined with Muromonab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Basiliximab is combined with Ibritumomab tiuxetan.
Tositumomab The risk or severity of adverse effects can be increased when Basiliximab is combined with Tositumomab.
Alemtuzumab The risk or severity of adverse effects can be increased when Basiliximab is combined with Alemtuzumab.
Alefacept The risk or severity of adverse effects can be increased when Basiliximab is combined with Alefacept.
Efalizumab The risk or severity of adverse effects can be increased when Basiliximab is combined with Efalizumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Basiliximab is combined with Antithymocyte immunoglobulin (rabbit).
Interferon alfa-2b The risk or severity of adverse effects can be increased when Basiliximab is combined with Interferon alfa-2b.
Daclizumab The risk or severity of adverse effects can be increased when Basiliximab is combined with Daclizumab.
Phenylalanine The risk or severity of adverse effects can be increased when Basiliximab is combined with Phenylalanine.
Flunisolide The risk or severity of adverse effects can be increased when Basiliximab is combined with Flunisolide.
Bortezomib The risk or severity of adverse effects can be increased when Basiliximab is combined with Bortezomib.
Cladribine Basiliximab may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Basiliximab is combined with Carmustine.
Amsacrine The risk or severity of adverse effects can be increased when Basiliximab is combined with Amsacrine.
Bleomycin The risk or severity of adverse effects can be increased when Basiliximab is combined with Bleomycin.
Chlorambucil The risk or severity of adverse effects can be increased when Basiliximab is combined with Chlorambucil.
Raltitrexed The risk or severity of adverse effects can be increased when Basiliximab is combined with Raltitrexed.
Mitomycin The risk or severity of adverse effects can be increased when Basiliximab is combined with Mitomycin.
Bexarotene The risk or severity of adverse effects can be increased when Basiliximab is combined with Bexarotene.
Vindesine The risk or severity of adverse effects can be increased when Basiliximab is combined with Vindesine.
Floxuridine The risk or severity of adverse effects can be increased when Basiliximab is combined with Floxuridine.
Indomethacin The risk or severity of adverse effects can be increased when Basiliximab is combined with Indomethacin.
Tioguanine The risk or severity of adverse effects can be increased when Basiliximab is combined with Tioguanine.
Vinorelbine The risk or severity of adverse effects can be increased when Basiliximab is combined with Vinorelbine.
Dexrazoxane The risk or severity of adverse effects can be increased when Basiliximab is combined with Dexrazoxane.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Basiliximab is combined with Beclomethasone dipropionate.
Sorafenib The risk or severity of adverse effects can be increased when Basiliximab is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Basiliximab is combined with Streptozocin.
Trifluridine The risk or severity of adverse effects can be increased when Basiliximab is combined with Trifluridine.
Gemcitabine The risk or severity of adverse effects can be increased when Basiliximab is combined with Gemcitabine.
Betamethasone The risk or severity of adverse effects can be increased when Basiliximab is combined with Betamethasone.
Teniposide The risk or severity of adverse effects can be increased when Basiliximab is combined with Teniposide.
Epirubicin The risk or severity of adverse effects can be increased when Basiliximab is combined with Epirubicin.
Chloramphenicol The risk or severity of adverse effects can be increased when Basiliximab is combined with Chloramphenicol.
Lenalidomide The risk or severity of adverse effects can be increased when Basiliximab is combined with Lenalidomide.
Altretamine The risk or severity of adverse effects can be increased when Basiliximab is combined with Altretamine.
Zidovudine The risk or severity of adverse effects can be increased when Basiliximab is combined with Zidovudine.
Cisplatin The risk or severity of adverse effects can be increased when Basiliximab is combined with Cisplatin.
Oxaliplatin The risk or severity of adverse effects can be increased when Basiliximab is combined with Oxaliplatin.
Cyclophosphamide The risk or severity of adverse effects can be increased when Basiliximab is combined with Cyclophosphamide.
Vincristine The risk or severity of adverse effects can be increased when Basiliximab is combined with Vincristine.
Fluorouracil The risk or severity of adverse effects can be increased when Basiliximab is combined with Fluorouracil.
Propylthiouracil The risk or severity of adverse effects can be increased when Basiliximab is combined with Propylthiouracil.
Pentostatin The risk or severity of adverse effects can be increased when Basiliximab is combined with Pentostatin.
Methotrexate The risk or severity of adverse effects can be increased when Basiliximab is combined with Methotrexate.
Carbamazepine The risk or severity of adverse effects can be increased when Basiliximab is combined with Carbamazepine.
Vinblastine The risk or severity of adverse effects can be increased when Basiliximab is combined with Vinblastine.
Fluticasone propionate The risk or severity of adverse effects can be increased when Basiliximab is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Basiliximab is combined with Fluocinolone acetonide.
Linezolid The risk or severity of adverse effects can be increased when Basiliximab is combined with Linezolid.
Imatinib The risk or severity of adverse effects can be increased when Basiliximab is combined with Imatinib.
Triamcinolone The risk or severity of adverse effects can be increased when Basiliximab is combined with Triamcinolone.
Clofarabine The risk or severity of adverse effects can be increased when Basiliximab is combined with Clofarabine.
Prednisone The risk or severity of adverse effects can be increased when Basiliximab is combined with Prednisone.
Pemetrexed The risk or severity of adverse effects can be increased when Basiliximab is combined with Pemetrexed.
Fludrocortisone The risk or severity of adverse effects can be increased when Basiliximab is combined with Fludrocortisone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Basiliximab is combined with Mycophenolate mofetil.
Daunorubicin The risk or severity of adverse effects can be increased when Basiliximab is combined with Daunorubicin.
Irinotecan The risk or severity of adverse effects can be increased when Basiliximab is combined with Irinotecan.
Methimazole The risk or severity of adverse effects can be increased when Basiliximab is combined with Methimazole.
Etoposide The risk or severity of adverse effects can be increased when Basiliximab is combined with Etoposide.
Sulfasalazine The risk or severity of adverse effects can be increased when Basiliximab is combined with Sulfasalazine.
Dacarbazine The risk or severity of adverse effects can be increased when Basiliximab is combined with Dacarbazine.
Temozolomide The risk or severity of adverse effects can be increased when Basiliximab is combined with Temozolomide.
Penicillamine The risk or severity of adverse effects can be increased when Basiliximab is combined with Penicillamine.
Prednisolone The risk or severity of adverse effects can be increased when Basiliximab is combined with Prednisolone.
Sirolimus The risk or severity of adverse effects can be increased when Basiliximab is combined with Sirolimus.
Mechlorethamine The risk or severity of adverse effects can be increased when Basiliximab is combined with Mechlorethamine.
Azacitidine The risk or severity of adverse effects can be increased when Basiliximab is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Basiliximab is combined with Carboplatin.
Methylprednisolone The risk or severity of adverse effects can be increased when Basiliximab is combined with Methylprednisolone.
Dactinomycin The risk or severity of adverse effects can be increased when Basiliximab is combined with Dactinomycin.
Cytarabine The risk or severity of adverse effects can be increased when Basiliximab is combined with Cytarabine.
Azathioprine The risk or severity of adverse effects can be increased when Basiliximab is combined with Azathioprine.
Doxorubicin The risk or severity of adverse effects can be increased when Basiliximab is combined with Doxorubicin.
Hydroxyurea The risk or severity of adverse effects can be increased when Basiliximab is combined with Hydroxyurea.
Busulfan The risk or severity of adverse effects can be increased when Basiliximab is combined with Busulfan.
Mycophenolic acid The risk or severity of adverse effects can be increased when Basiliximab is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Basiliximab is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Basiliximab is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Basiliximab is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Basiliximab is combined with Melphalan.

Target Protein

Interleukin-2 receptor subunit alpha IL2RA
Interleukin-2 receptor subunit beta IL2RB

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • Simulect
    Injection, powder, for solution • 10 mg/2.5mL • Intravenous • US • Approved
  • Simulect
    Injection, powder, for solution • 20 mg/5mL • Intravenous • US • Approved
  • Simulect
    Powder, for solution • 20 mg / vial • Intravenous • Canada • Approved
  • Simulect
    Injection, powder, for solution • 20 mg • Intravenous • EU • Approved
  • Simulect
    Injection, powder, for solution • 10 mg • Intravenous • EU • Approved
  • Simulect
    Injection • 10 mg • Intravenous • EU • Approved
  • Simulect
    - • 20 mg • Intravenous • EU • Approved

Sekuens Gen/Protein (FASTA)

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