Peringatan Keamanan

Vasopressin overdose is expected to present with consequences related to excessive vasoconstriction of peripheral, mesenteric, coronary vascular beds, hyponatremia, and possibly with ventricular tachyarrhythmias, rhabdomyolysis, and gastrointestinal symptoms. As vasopressin is rapidly metabolized and cleared, symptoms will resolve with cessation of vasopressin administration.L31413

Vasopressin

DB00067

biotech approved

Deskripsi

Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.A110, A111, A112, A113, A228008 Vasopressin is very similar to oxytocin, differing in the third and eighth amino acids.A228013 Despite a wide variety of functions, exogenous vasopressin is primarily used to control blood pressure during systemic shock by increasing vasoconstriction and renal fluid reuptake by acting through V1 and V2 cellular receptors.A228008, A228013, A228018, L31413

The vasopressive effect of posterior pituitary gland extracts was noted in 1895, while vasopressin itself was not purified until 1951. It has been used for more than five decades for varying conditions, including variceal bleeding, diabetes insipidus, and, more recently, vasodilatory shock.A228013 It is currently marketed under the trademark VASOSTRICT® by PAR Pharmaceuticals.L31413

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Vasopressin administered at 0.01-0.1 U/min has an apparent t<sub>1/2</sub> of ?10 minutes,[L31413] although half-lives of up to 44 minutes have been reported in the literature.
Volume Distribusi -
Klirens (Clearance) Vasopressin has a clearance of 9-25 mL/min/kg in patients with vasodilatory shock receiving 0.01-0.1 U/min of vasopressin.[L31413]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Animal studies suggest that vasopressin is metabolized by serine proteases, carboxypeptidases, and disulphide oxidoreductases, primarily in the liver and kidneys. These cleavage events occur at sites important for vasopressin's activity, and hence the metabolites are expected to be inactive.L31413

Rute Eliminasi

Vasopressin is primarily eliminated in the urine, where only 6% of the dose is excreted unchanged.L31413

Interaksi Obat

115 Data
Patent Blue The risk or severity of hypotension can be increased when Patent Blue is combined with Vasopressin.
Carbamazepine The risk or severity of water intoxication can be increased when Carbamazepine is combined with Vasopressin.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with Vasopressin.
Ardeparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Ardeparin.
Heparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Heparin.
Enoxaparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Enoxaparin.
Sulodexide The therapeutic efficacy of Vasopressin can be decreased when used in combination with Sulodexide.
Semuloparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Semuloparin.
Danaparoid The therapeutic efficacy of Vasopressin can be decreased when used in combination with Danaparoid.
Dalteparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Dalteparin.
Tinzaparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Tinzaparin.
Nadroparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Nadroparin.
Bemiparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Bemiparin.
Parnaparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Parnaparin.
Reviparin The therapeutic efficacy of Vasopressin can be decreased when used in combination with Reviparin.
Thyrotropin alfa Thyrotropin alfa may increase the vasoconstricting activities of Vasopressin.
Liothyronine Liothyronine may increase the vasoconstricting activities of Vasopressin.
Levothyroxine Levothyroxine may increase the vasoconstricting activities of Vasopressin.
Liotrix Liotrix may increase the vasoconstricting activities of Vasopressin.
Tiratricol Tiratricol may increase the vasoconstricting activities of Vasopressin.
Thyroid, porcine Thyroid, porcine may increase the vasoconstricting activities of Vasopressin.
Lidocaine The risk or severity of hypertension can be increased when Vasopressin is combined with Lidocaine.
Carbidopa Vasopressin may increase the hypertensive activities of Carbidopa.
Dipivefrin Vasopressin may increase the hypertensive activities of Dipivefrin.
Epinephrine Vasopressin may increase the hypertensive activities of Epinephrine.
Orciprenaline Vasopressin may increase the hypertensive activities of Orciprenaline.
Dobutamine Vasopressin may increase the hypertensive activities of Dobutamine.
Dopamine Vasopressin may increase the hypertensive activities of Dopamine.
Isoprenaline Vasopressin may increase the hypertensive activities of Isoprenaline.
Levodopa Vasopressin may increase the hypertensive activities of Levodopa.
6-hydroxydopa quinone Vasopressin may increase the hypertensive activities of 6-hydroxydopa quinone.
Debrisoquine Vasopressin may increase the hypertensive activities of Debrisoquine.
Droxidopa Vasopressin may increase the hypertensive activities of Droxidopa.
Etilevodopa Vasopressin may increase the hypertensive activities of Etilevodopa.
Levonordefrin Vasopressin may increase the hypertensive activities of Levonordefrin.
Protokylol Vasopressin may increase the hypertensive activities of Protokylol.
Racepinephrine Vasopressin may increase the hypertensive activities of Racepinephrine.
Dopexamine Vasopressin may increase the hypertensive activities of Dopexamine.
Dichloroisoproterenol Vasopressin may increase the hypertensive activities of Dichloroisoproterenol.
Reproterol Vasopressin may increase the hypertensive activities of Reproterol.
Theodrenaline Vasopressin may increase the hypertensive activities of Theodrenaline.
Melevodopa Vasopressin may increase the hypertensive activities of Melevodopa.
Ibopamine Vasopressin may increase the hypertensive activities of Ibopamine.
Adrenalone Vasopressin may increase the hypertensive activities of Adrenalone.
Deoxyepinephrine Vasopressin may increase the hypertensive activities of Deoxyepinephrine.
Indomethacin Indomethacin may increase the cardiodepressant activities of Vasopressin.
Botulinum toxin type B Botulinum toxin type B may increase the hypertensive activities of Vasopressin.
Botulinum toxin type A Botulinum toxin type A may increase the hypertensive activities of Vasopressin.
Nicotine Nicotine may increase the hypertensive activities of Vasopressin.
Mecamylamine Mecamylamine may increase the hypertensive activities of Vasopressin.
Pentolinium Pentolinium may increase the hypertensive activities of Vasopressin.
Trimethaphan Trimethaphan may increase the hypertensive activities of Vasopressin.
Tubocurarine Tubocurarine may increase the hypertensive activities of Vasopressin.
Tetraethylammonium Tetraethylammonium may increase the hypertensive activities of Vasopressin.
Hexamethonium Hexamethonium may increase the hypertensive activities of Vasopressin.
Cyclopentamine Cyclopentamine may increase the hypertensive activities of Vasopressin.
Furosemide Furosemide may increase the diuretic activities of Vasopressin.
Fluvoxamine Fluvoxamine may increase the fluid retaining and vasopressor activities of Vasopressin.
Citalopram Citalopram may increase the fluid retaining and vasopressor activities of Vasopressin.
Fluoxetine Fluoxetine may increase the fluid retaining and vasopressor activities of Vasopressin.
Duloxetine Duloxetine may increase the fluid retaining and vasopressor activities of Vasopressin.
Trazodone Trazodone may increase the fluid retaining and vasopressor activities of Vasopressin.
Paroxetine Paroxetine may increase the fluid retaining and vasopressor activities of Vasopressin.
Sertraline Sertraline may increase the fluid retaining and vasopressor activities of Vasopressin.
Sibutramine Sibutramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Nefazodone Nefazodone may increase the fluid retaining and vasopressor activities of Vasopressin.
Escitalopram Escitalopram may increase the fluid retaining and vasopressor activities of Vasopressin.
Zimelidine Zimelidine may increase the fluid retaining and vasopressor activities of Vasopressin.
Dapoxetine Dapoxetine may increase the fluid retaining and vasopressor activities of Vasopressin.
Milnacipran Milnacipran may increase the fluid retaining and vasopressor activities of Vasopressin.
Desvenlafaxine Desvenlafaxine may increase the fluid retaining and vasopressor activities of Vasopressin.
Seproxetine Seproxetine may increase the fluid retaining and vasopressor activities of Vasopressin.
Indalpine Indalpine may increase the fluid retaining and vasopressor activities of Vasopressin.
Ritanserin Ritanserin may increase the fluid retaining and vasopressor activities of Vasopressin.
Alaproclate Alaproclate may increase the fluid retaining and vasopressor activities of Vasopressin.
Amitriptyline Amitriptyline may increase the fluid retaining and vasopressor activities of Vasopressin.
Protriptyline Protriptyline may increase the fluid retaining and vasopressor activities of Vasopressin.
Imipramine Imipramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Nortriptyline Nortriptyline may increase the fluid retaining and vasopressor activities of Vasopressin.
Amoxapine Amoxapine may increase the fluid retaining and vasopressor activities of Vasopressin.
Trimipramine Trimipramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Doxepin Doxepin may increase the fluid retaining and vasopressor activities of Vasopressin.
Desipramine Desipramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Clomipramine Clomipramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Amineptine Amineptine may increase the fluid retaining and vasopressor activities of Vasopressin.
Dimetacrine Dimetacrine may increase the fluid retaining and vasopressor activities of Vasopressin.
Butriptyline Butriptyline may increase the fluid retaining and vasopressor activities of Vasopressin.
Dosulepin Dosulepin may increase the fluid retaining and vasopressor activities of Vasopressin.
Tianeptine Tianeptine may increase the fluid retaining and vasopressor activities of Vasopressin.
Oxaprotiline Oxaprotiline may increase the fluid retaining and vasopressor activities of Vasopressin.
Opipramol Opipramol may increase the fluid retaining and vasopressor activities of Vasopressin.
Amitriptylinoxide Amitriptylinoxide may increase the fluid retaining and vasopressor activities of Vasopressin.
Dibenzepin Dibenzepin may increase the fluid retaining and vasopressor activities of Vasopressin.
Quinupramine Quinupramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Melitracen Melitracen may increase the fluid retaining and vasopressor activities of Vasopressin.
Lofepramine Lofepramine may increase the fluid retaining and vasopressor activities of Vasopressin.
Iprindole Iprindole may increase the fluid retaining and vasopressor activities of Vasopressin.
Imipramine oxide Imipramine oxide may increase the fluid retaining and vasopressor activities of Vasopressin.
Haloperidol Haloperidol may increase the fluid retaining and vasopressor activities of Vasopressin.
Chlorpropamide Chlorpropamide may increase the fluid retaining and vasopressor activities of Vasopressin.

Target Protein

Vasopressin V2 receptor AVPR2
Vasopressin V1a receptor AVPR1A
Vasopressin V1b receptor AVPR1B
Oxytocin receptor OXTR

Referensi & Sumber

Synthesis reference: Nedumparambil A. Abraham, Hans U. Immer, Kazimir Sestanj, "Process for producing triglycyl-lysine vasopressin and intermediates therefor." U.S. Patent US4093610, issued June, 1963.
Artikel (PubMed)
  • PMID: 14647484
    Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ: Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology. 2004 Mar;29(3):483-93.
  • PMID: 17083331
    Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS 3rd: Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2007 Aug;6(6):540-51. Epub 2006 Nov 3.
  • PMID: 17122081
    Lolait SJ, Stewart LQ, Jessop DS, Young WS 3rd, O'Carroll AM: The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. 2007 Feb;148(2):849-56. Epub 2006 Nov 22.
  • PMID: 15555506
    Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd: Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004 Dec;46(5):638-45.
  • PMID: 7545469
    Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubes P: Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules. Blood. 1995 Oct 1;86(7):2760-6.
  • PMID: 29480411
    Lozic M, Sarenac O, Murphy D, Japundzic-Zigon N: Vasopressin, Central Autonomic Control and Blood Pressure Regulation. Curr Hypertens Rep. 2018 Feb 26;20(2):11. doi: 10.1007/s11906-018-0811-0.
  • PMID: 24621650
    Pelletier JS, Dicken B, Bigam D, Cheung PY: Cardiac effects of vasopressin. J Cardiovasc Pharmacol. 2014 Jul;64(1):100-7. doi: 10.1097/FJC.0000000000000092.
  • PMID: 25384691
    Wagener G, Bakker J: Vasopressin in cirrhosis and sepsis: physiology and clinical implications. Minerva Anestesiol. 2015 Dec;81(12):1377-83. Epub 2014 Nov 11.
Menampilkan 8 dari 9 artikel.

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