Interferon beta-1a

DB00060

biotech approved investigational

Deskripsi

Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10 hrs
Volume Distribusi -
Klirens (Clearance) * 33-55 L/hour [Healthy SC injection of 60 mcg]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid excessive or chronic alcohol consumption. Alcohol and interferon beta-1a can both cause hepatoxicity, therefore if they are used together they may have additive hepatoxic effects.

Interaksi Obat

207 Data
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Interferon beta-1a.
Caffeine The metabolism of Caffeine can be decreased when combined with Interferon beta-1a.
Dyphylline The metabolism of Dyphylline can be decreased when combined with Interferon beta-1a.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Interferon beta-1a.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Interferon beta-1a.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Interferon beta-1a.
Theobromine The metabolism of Theobromine can be decreased when combined with Interferon beta-1a.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Interferon beta-1a.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Interferon beta-1a.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Interferon beta-1a.
Xanthine The metabolism of Xanthine can be decreased when combined with Interferon beta-1a.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Interferon beta-1a.
Guanine The metabolism of Guanine can be decreased when combined with Interferon beta-1a.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Interferon beta-1a.
Peldesine The metabolism of Peldesine can be decreased when combined with Interferon beta-1a.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Interferon beta-1a.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Interferon beta-1a.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Interferon beta-1a.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Interferon beta-1a.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Interferon beta-1a.
Uric acid The metabolism of Uric acid can be decreased when combined with Interferon beta-1a.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Interferon beta-1a.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Interferon beta-1a.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Interferon beta-1a.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Interferon beta-1a.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Interferon beta-1a.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Interferon beta-1a.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Interferon beta-1a.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Interferon beta-1a.
Acefylline The metabolism of Acefylline can be decreased when combined with Interferon beta-1a.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Interferon beta-1a.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Interferon beta-1a.
Bufylline The metabolism of Bufylline can be decreased when combined with Interferon beta-1a.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Interferon beta-1a.
Furafylline The metabolism of Furafylline can be decreased when combined with Interferon beta-1a.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Interferon beta-1a.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Interferon beta-1a.
Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Interferon beta-1a.
Bortezomib The metabolism of Bortezomib can be decreased when combined with Interferon beta-1a.
Betaxolol The metabolism of Betaxolol can be decreased when combined with Interferon beta-1a.
Carmustine The metabolism of Carmustine can be decreased when combined with Interferon beta-1a.
Disopyramide The metabolism of Disopyramide can be decreased when combined with Interferon beta-1a.
Lidocaine The metabolism of Lidocaine can be decreased when combined with Interferon beta-1a.
Conjugated estrogens The metabolism of Conjugated estrogens can be decreased when combined with Interferon beta-1a.
Ropivacaine The metabolism of Ropivacaine can be decreased when combined with Interferon beta-1a.
Acetaminophen The metabolism of Acetaminophen can be decreased when combined with Interferon beta-1a.
Olanzapine The metabolism of Olanzapine can be decreased when combined with Interferon beta-1a.
Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Interferon beta-1a.
Clozapine The metabolism of Clozapine can be decreased when combined with Interferon beta-1a.
Grepafloxacin The metabolism of Grepafloxacin can be decreased when combined with Interferon beta-1a.
Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Interferon beta-1a.
Mexiletine The metabolism of Mexiletine can be decreased when combined with Interferon beta-1a.
Tacrine The metabolism of Tacrine can be decreased when combined with Interferon beta-1a.
Triamterene The metabolism of Triamterene can be decreased when combined with Interferon beta-1a.
Promazine The metabolism of Promazine can be decreased when combined with Interferon beta-1a.
Zolpidem The metabolism of Zolpidem can be decreased when combined with Interferon beta-1a.
Entecavir The metabolism of Entecavir can be decreased when combined with Interferon beta-1a.
Nabumetone The metabolism of Nabumetone can be decreased when combined with Interferon beta-1a.
Quinine The metabolism of Quinine can be decreased when combined with Interferon beta-1a.
Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Interferon beta-1a.
Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Interferon beta-1a.
Flutamide The metabolism of Flutamide can be decreased when combined with Interferon beta-1a.
Haloperidol The metabolism of Haloperidol can be decreased when combined with Interferon beta-1a.
Albendazole The metabolism of Albendazole can be decreased when combined with Interferon beta-1a.
Rofecoxib The metabolism of Rofecoxib can be decreased when combined with Interferon beta-1a.
Cinnarizine The metabolism of Cinnarizine can be decreased when combined with Interferon beta-1a.
Propranolol The metabolism of Propranolol can be decreased when combined with Interferon beta-1a.
Diclofenac The metabolism of Diclofenac can be decreased when combined with Interferon beta-1a.
Imatinib The metabolism of Imatinib can be decreased when combined with Interferon beta-1a.
Guanabenz The metabolism of Guanabenz can be decreased when combined with Interferon beta-1a.
Pemetrexed The metabolism of Pemetrexed can be decreased when combined with Interferon beta-1a.
Verapamil The metabolism of Verapamil can be decreased when combined with Interferon beta-1a.
Paroxetine The metabolism of Paroxetine can be decreased when combined with Interferon beta-1a.
Thiabendazole The metabolism of Thiabendazole can be decreased when combined with Interferon beta-1a.
Riluzole The metabolism of Riluzole can be decreased when combined with Interferon beta-1a.
Zileuton The metabolism of Zileuton can be decreased when combined with Interferon beta-1a.
Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Interferon beta-1a.
Estradiol The metabolism of Estradiol can be decreased when combined with Interferon beta-1a.
Acyclovir The metabolism of Acyclovir can be decreased when combined with Interferon beta-1a.
Naproxen The metabolism of Naproxen can be decreased when combined with Interferon beta-1a.
Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Interferon beta-1a.
Perphenazine The metabolism of Perphenazine can be decreased when combined with Interferon beta-1a.
Terbinafine The metabolism of Terbinafine can be decreased when combined with Interferon beta-1a.
Ranitidine The metabolism of Ranitidine can be decreased when combined with Interferon beta-1a.
Ethanol The metabolism of Ethanol can be decreased when combined with Interferon beta-1a.
Maprotiline The metabolism of Maprotiline can be decreased when combined with Interferon beta-1a.
Alosetron The metabolism of Alosetron can be decreased when combined with Interferon beta-1a.
Lomefloxacin The metabolism of Lomefloxacin can be decreased when combined with Interferon beta-1a.
Ramelteon The metabolism of Ramelteon can be decreased when combined with Interferon beta-1a.
Azathioprine The metabolism of Azathioprine can be decreased when combined with Interferon beta-1a.
Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Interferon beta-1a.
Levobupivacaine The metabolism of Levobupivacaine can be decreased when combined with Interferon beta-1a.
Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Interferon beta-1a.
Selegiline The metabolism of Selegiline can be decreased when combined with Interferon beta-1a.
Tocainide The metabolism of Tocainide can be decreased when combined with Interferon beta-1a.
Praziquantel The metabolism of Praziquantel can be decreased when combined with Interferon beta-1a.
Melatonin The metabolism of Melatonin can be decreased when combined with Interferon beta-1a.
Primaquine The metabolism of Primaquine can be decreased when combined with Interferon beta-1a.
Hesperetin The metabolism of Hesperetin can be decreased when combined with Interferon beta-1a.
Leflunomide The metabolism of Leflunomide can be decreased when combined with Interferon beta-1a.

Target Protein

Interferon alpha/beta receptor 1 IFNAR1
Interferon alpha/beta receptor 2 IFNAR2

Referensi & Sumber

Synthesis reference: Heinz-Jurgen Friesen, Sidney Pestka, "Preparation of homogeneous human fibroblast interferon." U.S. Patent US4289689, issued December, 1968.

Contoh Produk & Brand

Produk: 35 • International brands: 3
Produk
  • Avonex
    Injection, powder, lyophilized, for solution • 30 ug/1mL • Intramuscular • US • Approved
  • Avonex
    Kit • - • Intramuscular • US • Approved
  • Avonex
    Kit • - • Intramuscular • US • Approved
  • Avonex
    Kit • - • Intramuscular • US • Approved
  • Avonex
    Injection, solution • 30 ug/0.5mL • Intramuscular • US • Approved
  • Avonex
    Powder, for solution • - • Intramuscular • Canada • Approved
  • Avonex
    Powder, for solution • 60 mcg / mL • Intramuscular • Canada • Approved
  • Avonex
    Solution • 30 mcg / 0.5 mL • Intramuscular • Canada • Approved
Menampilkan 8 dari 35 produk.
International Brands
  • Betaferon — Bayer
  • Blastoferon — Sidus
  • Uribeta — Probiomed

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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