Cetrorelix

DB00050

small molecule approved investigational

Deskripsi

Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur.

Struktur Molekul 2D

Berat 1431.038

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) ~62.8 hours

Volume Distribusi * 1.16 L/kg

Klirens (Clearance) * 1.28 ml/min·kg [adult healthy female with 3 mg single SC administration]

Absorpsi

Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.

Metabolisme

In in vitro studies, cetrorelix was stable against phase I- and phase II-metabolism. Cetrorelix was transformed by peptidases, and the (1-4) peptide was the predominant metabolite.

Rute Eliminasi

Following subcutaneous administration of 10 mg cetrorelix to males and females, only unchanged cetrorelix was detected in urine.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Gonadotropin-releasing hormone receptor GNRHR

Lutropin-choriogonadotropic hormone receptor LHCGR

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 13 • International brands: 0

Produk

Cetrorelix

Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrorelix

Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrorelix acetate

Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrorelix acetate

Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrorelix Acetate

Kit • 0.25 mg/2mL • Subcutaneous • US • Generic • Approved
Cetrorelix Acetate

Injection, powder, for solution; Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrorelix Acetate

Injection, powder, for solution; Kit • 0.25 mg/1mL • Subcutaneous • US • Generic • Approved
Cetrotide

Kit • 3 mg/3mL • Subcutaneous • US • Approved

Menampilkan 8 dari 13 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.