No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised.
Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit of thyrotropin alfa, which is the effector region responsible for the stimulation of adenylate cyclase, displays close structural similarity with the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The beta subunit (TSHB) bestows its receptor specificity due to the uniqueness to TSH. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tolevamer | Tolevamer can cause a decrease in the absorption of Thyrotropin alfa resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Diethylstilbestrol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Diethylstilbestrol. |
| Chlorotrianisene | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Chlorotrianisene. |
| Conjugated estrogens | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Conjugated estrogens. |
| Estradiol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estradiol. |
| Ethinylestradiol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Ethinylestradiol. |
| Mestranol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Mestranol. |
| Estrone sulfate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estrone sulfate. |
| Quinestrol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Quinestrol. |
| Hexestrol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Hexestrol. |
| Tibolone | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Tibolone. |
| Synthetic Conjugated Estrogens, A | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Synthetic Conjugated Estrogens, A. |
| Synthetic Conjugated Estrogens, B | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Synthetic Conjugated Estrogens, B. |
| Polyestradiol phosphate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Polyestradiol phosphate. |
| Esterified estrogens | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Esterified estrogens. |
| Zeranol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Zeranol. |
| Equol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Equol. |
| Methallenestril | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Methallenestril. |
| Epimestrol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Epimestrol. |
| Moxestrol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Moxestrol. |
| Estradiol acetate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estradiol acetate. |
| Estradiol benzoate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estradiol benzoate. |
| Estradiol cypionate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estradiol cypionate. |
| Estradiol valerate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estradiol valerate. |
| Biochanin A | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Biochanin A. |
| Formononetin | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Formononetin. |
| Estriol | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Estriol. |
| Fluvoxamine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Fluvoxamine. |
| Citalopram | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Citalopram. |
| Fluoxetine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Fluoxetine. |
| Duloxetine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Duloxetine. |
| Trazodone | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Trazodone. |
| Paroxetine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Paroxetine. |
| Sertraline | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Sertraline. |
| Sibutramine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Sibutramine. |
| Nefazodone | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Nefazodone. |
| Escitalopram | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Escitalopram. |
| Zimelidine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Zimelidine. |
| Dapoxetine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Dapoxetine. |
| Milnacipran | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Milnacipran. |
| Desvenlafaxine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Desvenlafaxine. |
| Seproxetine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Seproxetine. |
| Indalpine | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Indalpine. |
| Ritanserin | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Ritanserin. |
| Alaproclate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Alaproclate. |
| Colesevelam | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Colesevelam. |
| Calcium acetate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium acetate. |
| Calcium glucoheptonate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium glucoheptonate. |
| Calcium chloride | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium chloride. |
| Calcium | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium. |
| Calcium carbonate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium carbonate. |
| Calcium citrate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium citrate. |
| Calcium gluconate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium gluconate. |
| Calcium Phosphate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium Phosphate. |
| Calcium glubionate anhydrous | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium glubionate anhydrous. |
| Calcium lactate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium lactate. |
| Calcium lactate gluconate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium lactate gluconate. |
| Calcium pangamate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium pangamate. |
| Calcium levulinate | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium levulinate. |
| Calcium cation | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium cation. |
| Calcium polycarbophil | The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium polycarbophil. |
| Lanthanum carbonate | Lanthanum carbonate can cause a decrease in the absorption of Thyrotropin alfa resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Piracetam | The risk or severity of confusion, irritability, and sleep disorders can be increased when Thyrotropin alfa is combined with Piracetam. |
| Metformin | The therapeutic efficacy of Metformin can be decreased when used in combination with Thyrotropin alfa. |
| Vasopressin | Thyrotropin alfa may increase the vasoconstricting activities of Vasopressin. |
| Felypressin | Thyrotropin alfa may increase the vasoconstricting activities of Felypressin. |
| Methysergide | Thyrotropin alfa may increase the vasoconstricting activities of Methysergide. |
| Dihydroergotamine | Thyrotropin alfa may increase the vasoconstricting activities of Dihydroergotamine. |
| Sumatriptan | Thyrotropin alfa may increase the vasoconstricting activities of Sumatriptan. |
| Ergotamine | Thyrotropin alfa may increase the vasoconstricting activities of Ergotamine. |
| Cocaine | Thyrotropin alfa may increase the vasoconstricting activities of Cocaine. |
| Naratriptan | Thyrotropin alfa may increase the vasoconstricting activities of Naratriptan. |
| S-Ethylisothiourea | Thyrotropin alfa may increase the vasoconstricting activities of S-Ethylisothiourea. |
| Terlipressin | Thyrotropin alfa may increase the vasoconstricting activities of Terlipressin. |
| Calyculin A | Thyrotropin alfa may increase the vasoconstricting activities of Calyculin A. |
| Xylometazoline | Thyrotropin alfa may increase the vasoconstricting activities of Xylometazoline. |
| Levonordefrin | The risk or severity of adverse effects can be increased when Levonordefrin is combined with Thyrotropin alfa. |
| Naphazoline | The risk or severity of adverse effects can be increased when Naphazoline is combined with Thyrotropin alfa. |
| Cirazoline | Thyrotropin alfa may increase the vasoconstricting activities of Cirazoline. |
| Angiotensin II | Thyrotropin alfa may increase the vasoconstricting activities of Angiotensin II. |
| Octopamine | Thyrotropin alfa may increase the vasoconstricting activities of Octopamine. |
| Adrenalone | Thyrotropin alfa may increase the vasoconstricting activities of Adrenalone. |
| Ornipressin | Thyrotropin alfa may increase the vasoconstricting activities of Ornipressin. |
| Angiotensinamide | Thyrotropin alfa may increase the vasoconstricting activities of Angiotensinamide. |
| Lypressin | Thyrotropin alfa may increase the vasoconstricting activities of Lypressin. |
| Aminosalicylic acid | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Aminosalicylic acid. |
| Mesalazine | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Mesalazine. |
| Sulfasalazine | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Sulfasalazine. |
| Diflunisal | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Diflunisal. |
| Salicylic acid | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Salicylic acid. |
| Acetylsalicylic acid | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Acetylsalicylic acid. |
| Balsalazide | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Balsalazide. |
| Olsalazine | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Olsalazine. |
| Bismuth subsalicylate | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Bismuth subsalicylate. |
| Dersalazine | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Dersalazine. |
| Phenyl aminosalicylate | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Phenyl aminosalicylate. |
| Methyl salicylate | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Methyl salicylate. |
| Nitroaspirin | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Nitroaspirin. |
| Aloxiprin | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Aloxiprin. |
| Guacetisal | The therapeutic efficacy of Thyrotropin alfa can be increased when used in combination with Guacetisal. |