Darbepoetin alfa

DB00012

biotech approved investigational

Deskripsi

Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Administer iron supplement. When initiating an erythropoiesis-stimulating agent, evaluate iron stores and start iron supplementation if indicated. Most patients with chronic kidney disease require iron supplementation while taking an erythropoiesis-stimulating agent.

Interaksi Obat

585 Data
Cyclophosphamide The risk or severity of pulmonary toxicity can be increased when Darbepoetin alfa is combined with Cyclophosphamide.
Nandrolone phenpropionate The therapeutic efficacy of Darbepoetin alfa can be increased when used in combination with Nandrolone phenpropionate.
Nandrolone decanoate The therapeutic efficacy of Darbepoetin alfa can be increased when used in combination with Nandrolone decanoate.
Nandrolone The therapeutic efficacy of Darbepoetin alfa can be increased when used in combination with Nandrolone.
Vindesine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vindesine.
Vinorelbine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vinorelbine.
Vincristine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vincristine.
Vinblastine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vinblastine.
Vintafolide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vintafolide.
Vinflunine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vinflunine.
Vincamine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vincamine.
Lenalidomide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Lenalidomide.
Thalidomide The risk or severity of thromboembolism can be increased when Thalidomide is combined with Darbepoetin alfa.
Pomalidomide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pomalidomide.
Cetuximab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cetuximab.
Denileukin diftitox The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Denileukin diftitox.
Leuprolide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Leuprolide.
Peginterferon alfa-2a The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Peginterferon alfa-2a.
Goserelin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Goserelin.
Asparaginase Escherichia coli The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Asparaginase Escherichia coli.
Aldesleukin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Aldesleukin.
Gemtuzumab ozogamicin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Gemtuzumab ozogamicin.
Pegaspargase The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pegaspargase.
Trastuzumab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Trastuzumab.
Rituximab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Rituximab.
Tositumomab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tositumomab.
Alemtuzumab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Alemtuzumab.
Octreotide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Octreotide.
Interferon alfa-2b The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Interferon alfa-2b.
Bevacizumab The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bevacizumab.
Masoprocol The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Masoprocol.
Bortezomib The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bortezomib.
Pipobroman The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pipobroman.
Cladribine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cladribine.
Cabergoline The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cabergoline.
Anagrelide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Anagrelide.
Carmustine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Carmustine.
Chlorotrianisene The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Chlorotrianisene.
Amsacrine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Amsacrine.
Pamidronic acid The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pamidronic acid.
Bleomycin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bleomycin.
Chlorambucil The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Chlorambucil.
Raltitrexed The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Raltitrexed.
Mitomycin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Mitomycin.
Bexarotene The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bexarotene.
Valproic acid The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Valproic acid.
Gefitinib The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Gefitinib.
Floxuridine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Floxuridine.
Megestrol acetate The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Megestrol acetate.
Tioguanine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tioguanine.
Aminoglutethimide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Aminoglutethimide.
Valrubicin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Valrubicin.
Sorafenib The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Sorafenib.
Streptozocin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Streptozocin.
Trifluridine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Trifluridine.
Gemcitabine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Gemcitabine.
Teniposide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Teniposide.
Epirubicin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Epirubicin.
Altretamine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Altretamine.
Flutamide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Flutamide.
Cisplatin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cisplatin.
Alitretinoin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Alitretinoin.
Oxaliplatin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Oxaliplatin.
Erlotinib The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Erlotinib.
Toremifene The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Toremifene.
Fluorouracil The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Fluorouracil.
Pentostatin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pentostatin.
Methotrexate The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Methotrexate.
Medroxyprogesterone acetate The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Medroxyprogesterone acetate.
Imatinib The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Imatinib.
Clofarabine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Clofarabine.
Prednisone The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Prednisone.
Pemetrexed The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pemetrexed.
Mitotane The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Mitotane.
Nilutamide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Nilutamide.
Tamoxifen The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tamoxifen.
Daunorubicin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Daunorubicin.
Porfimer sodium The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Porfimer sodium.
Tretinoin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Tretinoin.
Irinotecan The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Irinotecan.
Etoposide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Etoposide.
Uracil mustard The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Uracil mustard.
Dacarbazine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Dacarbazine.
Temozolomide The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Temozolomide.
Aminolevulinic acid The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Aminolevulinic acid.
Prednisolone The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Prednisolone.
Mechlorethamine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Mechlorethamine.
Testolactone The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Testolactone.
Azacitidine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Azacitidine.
Fulvestrant The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Fulvestrant.
Carboplatin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Carboplatin.
Methylprednisolone The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Methylprednisolone.
Dactinomycin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Dactinomycin.
Cytarabine The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Cytarabine.
Exemestane The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Exemestane.
Doxorubicin The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Doxorubicin.
Hydroxyurea The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Hydroxyurea.
Letrozole The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Letrozole.
Busulfan The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Busulfan.
Topotecan The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Topotecan.

Target Protein

Erythropoietin receptor EPOR

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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