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Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
4 (100.0%)
Genomik
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Referensi
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Hasil Pencarian (4)

Eszopiclone Approved DB00402
small molecule | CAS: 138729-47-2

Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone …

Kategori:
Benzodiazepine hypnotics and sedativesCentral Nervous System AgentsCentral Nervous System Depressants +18
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Translocator proteinGABA(A) Receptor +3
Waktu ParuhThe half-life is 6.…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
Lemborexant Approved DB11951
small molecule | CAS: 1369764-02-2

Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driv…

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP2B6 Inducers +17
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhThe half-life for l…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Pagoclone DB04903
small molecule | CAS: 133737-32-3

Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which h…

Kategori:
Central Nervous System DepressantsGABA AgentsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zopiclone Approved DB01198
small molecule | CAS: 43200-80-2

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.

Kategori:
Aza CompoundsBenzodiazepine hypnotics and sedativesCentral Nervous System Agents +16
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +2
Waktu ParuhElimination half li…
Vol. Distribusi-
Klirens-
Genetik -