Hasil Filter

3

Total database: 17430
Struktur (SMILES)
3 (100.0%)
Target
3 (100.0%)
Genomik
1 (33.3%)
Referensi
3 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Isavuconazonium Approved DB06636
small molecule | CAS: 742049-41-8

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba.[A38834] …

Kategori:
Anti-Infective AgentsAntifungal AgentsAzole Antifungals +31
Target Protein:
Lanosterol 14-alpha demethylase
Waktu ParuhBased on a populati…
Vol. DistribusiIsavuconazole is ex…
KlirensIn healthy subjects…
Genetik -
Ketoconazole Approved DB01026
small molecule | CAS: 65277-42-1

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.[FDA Label] It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity…

Kategori:
14-alpha Demethylase InhibitorsAgents causing hyperkalemiaAnti-Infective Agents +55
Target Protein:
Lanosterol 14-alpha demethylaseLanosterol 14-alpha demethylaseSteroid 17-alpha-hydroxylase/17,20 lyase +5
Waktu ParuhKetoconazole experi…
Vol. DistribusiKetoconazole has an…
KlirensKetoconazole has an…
Genetik -
Voriconazole Approved DB00582
small molecule | CAS: 137234-62-9

Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis,…

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +35
Target Protein:
Lanosterol 14-alpha demethylase
Gen Terkait:
CYP2C19 CYP2C19 CYP2C19
Waktu ParuhVoriconazole follow…
Vol. DistribusiThe estimated volum…
KlirensThe clearance of vo…
Genetik 3 Varian