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Total database: 17430
Struktur (SMILES)
2 (66.7%)
Target
2 (66.7%)
Genomik
1 (33.3%)
Referensi
3 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Atogepant Approved DB16098
small molecule | CAS: 1374248-81-3

Atogepant is an oral antagonist of calcitonin gene-related peptide (CGRP) receptors indicated for the prevention of episodic migraine headaches. It was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021.[L38814] While…

Kategori:
AnalgesicsAntimigraine PreparationsBCRP/ABCG2 Substrates +14
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent o…
Genetik -
DP-VPA DB05821
small molecule

DP-VPA is D-Pharm's proprietary lipid modified version of valproic acid (VPA) that demonstrate that DP-VPA is well-tolerated in patients with resistant epilepsy and has a marked effect on reducing seizure frequency.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Valproic acid Approved DB00313
small molecule | CAS: 99-66-1

Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton.[A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a…

Kategori:
Acids, AcyclicAnti-epileptic AgentAnticonvulsants +68
Target Protein:
4-aminobutyrate aminotransferase, mitochondrialGlycogen synthase kinase-3 alphaHistone deacetylase 9 +13
Gen Terkait:
POLG POLG
Waktu Paruh13-19 hours.[label]…
Vol. Distribusi11 L/1.73m<sup>2</s…
Klirens0.56 L/hr/m<sup>2</…
Genetik 2 Varian