Hasil Pencarian (2)
small molecule | CAS: 1206161-97-8
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, and inflammatory disease that causes synovial joint symptoms and can limit range of motion in severe cases.[A221451,A221456] The disease is associated with extra-articular manifestations, progressi…
Kategori:
Antineoplastic and Immunomodulating AgentsArthritis, Rheumatoid, drug therapyImmunosuppressive Agents
+5
Target Protein:
Tyrosine-protein kinase JAK1
Waktu ParuhThe half-life of fi…
Vol. Distribusi-
Klirens-
Genetik
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small molecule | CAS: 477600-75-2
Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds…
Kategori:
Antineoplastic and Immunomodulating AgentsAntirheumatic AgentsBiologics for Rheumatoid Arthritis Treatment
+14
Target Protein:
Tyrosine-protein kinase JAK1Tyrosine-protein kinase JAK2Tyrosine-protein kinase JAK3
+1
Waktu Paruh~3 hours
Vol. DistribusiVd= 87L after intra…
Klirens-
Genetik
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