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Total database: 17430
Struktur (SMILES)
10 (71.4%)
Target
11 (78.6%)
Genomik
0 (0%)
Referensi
14 (100.0%)

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Hasil Pencarian (14)

small molecule | CAS: 300-39-0

A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE). [PubCh…

Kategori:
Antithyroid agentsThyroid Products
Target Protein:
cAMP-dependent protein kinase inhibitor alphacAMP-dependent protein kinase catalytic subunit alphaAlpha-amylase G-6 +3
Waktu Paruh-
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Genetik -
biotech

Deskripsi belum tersedia.

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Albumin human Approved DB00062
biotech | CAS: 9048-46-8

Human serum albumin is the primary protein present in human blood plasma. The main function of albumin is to maintain the oncotic pressure of blood [A33706]. It binds to water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T…

Kategori:
AlbuminsAmino Acids, Peptides, and ProteinsBlood and Blood Forming Organs +13
Target Protein:
Nitric oxide
Waktu Paruh-
Vol. DistribusiAlbumin is distribu…
Klirens-
Genetik -
D-Phenylalanine DB02556
small molecule | CAS: 673-06-3

An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]

Target Protein:
Kynurenine--oxoglutarate transaminase 1Corticoliberin
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Dextrothyroxine Approved DB00509
small molecule | CAS: 51-49-0

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and …

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +5
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor betaThyroid peroxidase
Waktu Paruh-
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Iodide I-123 Approved DB09420
small molecule | CAS: 69239-56-1

Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid g…

Kategori:
Diagnostic RadiopharmaceuticalsElementsHalogens +6
Waktu ParuhIodine-123 decays b…
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Letrozole Approved DB01006
small molecule | CAS: 112809-51-5

Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not signifi…

Kategori:
Agents Causing Muscle ToxicityAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +21
Target Protein:
Aromatase
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensThe average clearan…
Genetik -
Levothyroxine Approved DB00451
small molecule | CAS: 51-48-9

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland.[F4633] Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition w…

Kategori:
Agents used to treat hypothyroidismAmino AcidsAmino Acids, Aromatic +16
Target Protein:
Integrin alpha-VIntegrin beta-3Thyroid hormone receptor alpha +1
Waktu ParuhT<sub>4</sub> half-…
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Liothyronine Approved DB00279
small molecule | CAS: 6893-02-3

Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.[T457…

Kategori:
Agents used to treat hypothyroidismDrugs that are Mainly Renally ExcretedHormones +12
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor betaProliferating cell nuclear antigen
Waktu ParuhThe half-life of li…
Vol. DistribusiThe reported volume…
KlirensThere are no report…
Genetik -
Liotrix Approved DB01583
small molecule | CAS: 8065-29-0

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum l…

Kategori:
Agents used to treat hypothyroidismAmino AcidsAmino Acids, Aromatic +19
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor beta
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Phenylalanine Approved DB00120
small molecule | CAS: 63-91-2

Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +7
Target Protein:
Tyrosine 3-monooxygenaseTyrosine aminotransferaseLarge neutral amino acids transporter small subunit 2 +4
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Propylthiouracil Approved DB00550
small molecule | CAS: 51-52-5

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)

Kategori:
Agents Causing Muscle ToxicityAntimetabolitesAntithyroid agents +14
Target Protein:
Type I iodothyronine deiodinaseThyroid peroxidase
Waktu Paruh2 hours
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Thyroglobulin Approved DB01584
biotech | CAS: 9010-34-8

Thyroglobulin (also known as Tg) is an enzyme thyroid hormone used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The active form of thyroxine, triiodothyronine, is produced both within the thyroid gland and per…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlobulins +4
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Thyroid, porcine Approved DB09100
biotech

Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since…

Kategori:
Agents used to treat hypothyroidismThyroid Products
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor beta
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
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