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Total database: 17430
Struktur (SMILES)
3 (75.0%)
Target
3 (75.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Hasil Pencarian (4)

Deutetrabenazine Approved DB12161
small molecule | CAS: 1392826-25-3

Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated [DB04844] [A…

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2D6 SubstratesCytochrome P-450 CYP3A Substrates +11
Target Protein:
Synaptic vesicular amine transporter
Waktu ParuhThe half-life of to…
Vol. DistribusiThe median volume o…
KlirensIn patients with Hu…
Genetik -
NBI-98782 Approved DB16905
small molecule | CAS: 85081-18-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrabenazine Approved DB04844
small molecule | CAS: 58-46-8

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August…

Kategori:
Adrenergic AgentsCytochrome P-450 CYP2D6 SubstratesCytochrome P-450 Substrates +11
Target Protein:
Synaptic vesicular amine transporterD(2) dopamine receptor
Waktu ParuhThere is interindiv…
Vol. DistribusiSteady State, IV, i…
KlirensIV, 1.67 L/min in H…
Genetik -
Valbenazine Approved DB11915
small molecule | CAS: 1025504-45-3

Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia ha…

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +11
Target Protein:
Synaptic vesicular amine transporter
Waktu ParuhBoth Valbenazine an…
Vol. DistribusiThe mean steady-sta…
KlirensValbenazine has a m…
Genetik -