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Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
4 (100.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Doxazosin Approved DB00590
small molecule | CAS: 74191-85-8

Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin].[A180661] Because of its long-lasting e…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +22
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorHERG human cardiac K+ channel +1
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of do…
Genetik -
Dutasteride Approved DB01126
small molecule | CAS: 164656-23-9

Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5?-reductase inhibitor that works by blocking both isoforms of 5?-reductase enzymes in a potent, selective, and irreversible manner.[A1909] Type I…

Kategori:
5-alpha Reductase InhibitorsAdrenergic alpha-AntagonistsAdrenergic Antagonists +14
Target Protein:
3-oxo-5-alpha-steroid 4-dehydrogenase 1Polyprenal reductase3-oxo-5-alpha-steroid 4-dehydrogenase 2
Waktu ParuhThe terminal elimin…
Vol. DistribusiDutasteride display…
KlirensIn a study of healt…
Genetik -
Finasteride Approved DB01216
small molecule | CAS: 98319-26-7

Finasteride is a synthetic 4-azasteroid compound [L10565] and specific inhibitor of steroid Type II 5?-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5?-dihydrotestosterone (DHT). It works in a similar fashion as [dut…

Kategori:
5-alpha Reductase InhibitorsAdrenergic alpha-AntagonistsAdrenergic Antagonists +22
Target Protein:
3-oxo-5-alpha-steroid 4-dehydrogenase 2Polyprenal reductase3-oxo-5-alpha-steroid 4-dehydrogenase 1 +1
Waktu ParuhIn healthy young su…
Vol. DistribusiThe volume of distr…
KlirensIn healthy young su…
Genetik -
Tamsulosin Approved DB00706
small molecule | CAS: 106133-20-4

Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.[Label] It is indicated for the treatment of signs and symptoms of benign prostatic hype…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +22
Target Protein:
Alpha-1A adrenergic receptorAlpha-1D adrenergic receptorAlpha-1B adrenergic receptor
Waktu ParuhThe half life in fa…
Vol. Distribusi16L after intraveno…
Klirens2.88L/h.[Label]
Genetik -