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Total database: 17430
Struktur (SMILES)
5 (100.0%)
Target
5 (100.0%)
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Hasil Pencarian (5)

Ambrisentan Approved DB06403
small molecule | CAS: 177036-94-1

Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and de…

Kategori:
Acids, CarbocyclicAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +15
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhAmbrisentan has a t…
Vol. DistribusiAmbrisentan has a l…
KlirensThe mean oral clear…
Genetik -
Avanafil Approved DB06237
small molecule | CAS: 330784-47-9

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity th…

Kategori:
BCRP/ABCG2 InhibitorsCytochrome P-450 CYP2C9 SubstratesCytochrome P-450 CYP3A Substrates +9
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
Waktu ParuhStudies have demons…
Vol. DistribusiThe apparent volume…
Klirens-
Genetik -
Macitentan Approved DB08932
small molecule | CAS: 441798-33-0

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] in part due to its lower risk of hepatotox…

Kategori:
AmidesAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +13
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhThe half-life of el…
Vol. DistribusiMacitentan has an a…
KlirensClearance data was …
Genetik -
Tadalafil Approved DB00820
small molecule | CAS: 171596-29-5

Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED …

Kategori:
5-alpha Reductase InhibitorsAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +20
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesteraseDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ARetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Waktu ParuhThe mean half-life …
Vol. DistribusiTadalafil has a mea…
KlirensThe mean apparent o…
Genetik -
Vardenafil Approved DB00862
small molecule | CAS: 224785-90-4

Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from n…

Kategori:
Cardiovascular AgentsCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 Inhibitors (weak) +30
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesteraseRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Waktu ParuhVardenafil and its …
Vol. DistribusiVardenafil has a st…
KlirensVardenafil has a to…
Genetik -