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Total database: 17430
Struktur (SMILES)
3 (100.0%)
Target
3 (100.0%)
Genomik
0 (0%)
Referensi
3 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Daridorexant Approved DB15031
small molecule | CAS: 1505484-82-1

Daridorexant, formerly known as nemorexant, is a selective dual orexin receptor antagonist used to treat insomnia. Insomnia is characterized by difficulties with sleep onset and/or sleep maintenance and impairment of daytime functioning. It chronically affect…

Kategori:
Central Nervous System DepressantsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +6
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhThe terminal half-l…
Vol. DistribusiDaridorexant has a …
KlirensThere is limited in…
Genetik -
Lemborexant Approved DB11951
small molecule | CAS: 1369764-02-2

Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driv…

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP2B6 Inducers +17
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhThe half-life for l…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Suvorexant Approved DB09034
small molecule | CAS: 1030377-33-3

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +13
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhMean half life is a…
Vol. DistribusiMean volume of dist…
Klirens-
Genetik -