Hasil Pencarian (2)
small molecule | CAS: 625115-55-1
Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic …
Kategori:
Antihypertensive AgentsAntihypertensives for Pulmonary Arterial HypertensionBCRP/ABCG2 Substrates
+11
Target Protein:
Retinal guanylyl cyclase 1Guanylate cyclase soluble subunit alpha-2
Waktu ParuhAbout 12 hours in p…
Vol. DistribusiVolume of distribut…
Klirens-
Genetik
-
small molecule | CAS: 1350653-20-1
Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations.[L31153] A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascu…
Kategori:
BCRP/ABCG2 SubstratesCardiac TherapyGuanylate Cyclase Stimulators
+8
Target Protein:
Retinal guanylyl cyclase 1Guanylate cyclase soluble subunit beta-1
Waktu ParuhIn patients with he…
Vol. DistribusiIn healthy subjects…
KlirensVericiguat is a low…
Genetik
-