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Total database: 17430
Struktur (SMILES)
11 (78.6%)
Target
10 (71.4%)
Genomik
2 (14.3%)
Referensi
14 (100.0%)

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Hasil Pencarian (14)

Elbasvir Approved DB11574
small molecule | CAS: 1370468-36-2

Elbasvir is a direct-acting antiviral medication used as part of combination therapy to treat chronic hepatitis C, an infectious liver disease caused by infection with hepatitis C virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine d…

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +18
Target Protein:
Nonstructural protein 5A
Waktu ParuhThe geometric mean …
Vol. DistribusiElbasvir has an est…
KlirensThe clearance of el…
Genetik -
EMZ702 DB05021
small molecule

EMZ702, a non-toxic agent that has strong anti-viral synergy with interferon, is an ideal candidate for combination with current standard hepatitis C treatments. EMZ702 has an excellent safety profile and the combination of EMZ702 with interferon and ribaviri…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ledipasvir Approved DB09027
small molecule | CAS: 1256388-51-8

Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized int…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +10
Target Protein:
Genome polyproteinNonstructural protein 5A
Waktu ParuhThe median terminal…
Vol. Distribusi-
Klirens-
Genetik -
Ombitasvir Approved DB09296
small molecule | CAS: 1258226-87-7

Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine…

Kategori:
AmidesAminesAmino Acids +18
Target Protein:
Nonstructural protein 5AGenome polyprotein
Waktu ParuhOmbitasvir has a ha…
Vol. DistribusiOmbitasvir has a vo…
KlirensClearance of Ombita…
Genetik -
Peginterferon alfa-2b Approved DB00022
biotech | CAS: 215647-85-1

Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized in…

Kategori:
Adjuvants, ImmunologicAlcoholsAlfa Interferons +34
Target Protein:
Interferon alpha/beta receptor 1Interferon alpha/beta receptor 2
Gen Terkait:
IFNL3
Waktu ParuhThe mean half-life …
Vol. Distribusi-
KlirensThe estimated appar…
Genetik 1 Varian
biotech | CAS: 914617-98-4

Peginterferon lambda-1a is under investigation in clinical trial NCT01754974 (Safety and Efficacy Study of Peginterferon Lambda-1a vs. Peginterferon Alfa-2a, Plus Ribavirin in Subjects With Genotype 1 Hepatitis C).

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ribavirin Approved DB00811
small molecule | CAS: 36791-04-5

Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. It is primarily indicated for use in treating hepatitis C and viral he…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntimetabolites +13
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1RNA-directed RNA polymerase LGenome polyprotein +2
Gen Terkait:
IFNL3
Waktu ParuhThe terminal half-l…
Vol. DistribusiRibavirin displays …
KlirensThe total apparent …
Genetik 1 Varian
small molecule | CAS: 1352921-29-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 40925-28-8

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsCarbohydrates +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ritonavir Approved DB00503
small molecule | CAS: 155213-67-5

Ritonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimens with low-dose ritona…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnti-HIV Agents +69
Target Protein:
Gag-Pol polyproteinPol polyproteinNuclear receptor subfamily 1 group I member 2
Waktu ParuhThe approximate hal…
Vol. DistribusiThe estimated volum…
KlirensThe apparent oral c…
Genetik -
Simeprevir Approved DB06290
small molecule | CAS: 923604-59-5

Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, w…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +37
Target Protein:
Genome polyproteinNS3 proteaseGenome polyprotein
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of si…
Genetik -
Sofosbuvir Approved DB08934
small molecule | CAS: 1190307-88-0

Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is c…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +18
Target Protein:
Genome polyproteinRNA-dependent RNA-polymerase
Waktu ParuhSofosbuvir has a te…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of so…
Genetik -
Taribavirin DB06408
small molecule | CAS: 119567-79-2

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsNucleic Acids, Nucleotides, and Nucleosides +3
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1DNARNA-directed RNA polymerase L +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
TMC-649128 DB15152
small molecule | CAS: 1019639-33-8

TMC-649128 is under investigation in clinical trial NCT01391117 (TMC649128HPC1002 - a Trial inGenotype 1 Hepatitis C Virus (HCV) - Infected Participants to Determine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of TMC649128, Alone and Com…

Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
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Genetik -