Hasil Filter

8

Total database: 17430
Struktur (SMILES)
6 (75.0%)
Target
4 (50.0%)
Genomik
0 (0%)
Referensi
8 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (8)

Cinchonidine DB16831
small molecule | CAS: 485-71-2

Deskripsi belum tersedia.

Kategori:
Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Halofantrine Approved DB01218
small molecule | CAS: 69756-53-2

Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poiso…

Kategori:
Agents that reduce seizure thresholdAnti-Infective AgentsAntimalarials +13
Target Protein:
Fe(II)-protoporphyrin IXCalmodulin-1Calmodulin-3 +3
Waktu Paruh6-10 days
Vol. Distribusi-
Klirens-
Genetik -
Hydroquinine DB13718
small molecule | CAS: 522-66-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiarrhythmic agentsAutonomic Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Opium Approved DB11130
small molecule | CAS: 8008-60-4

Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it wa…

Kategori:
Alimentary Tract and MetabolismAnalgesicsAntidiarrheals +25
Target Protein:
Delta-type opioid receptorKappa-type opioid receptorMu-type opioid receptor
Waktu ParuhThe half-life of op…
Vol. DistribusiOpium presents a la…
Klirens-
Genetik -
small molecule | CAS: 87827-02-9

Penequinine, Penehyclidine is under investigation in clinical trial NCT02644876 (Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinidine Approved DB00908
small molecule | CAS: 56-54-2

Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.[A38016,A250050] Quinidine is considered the first antiar…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +81
Target Protein:
Sodium channel protein type 5 subunit alphaPotassium channel subfamily K member 1Potassium channel subfamily K member 6 +4
Waktu ParuhThe elimination hal…
Vol. DistribusiQuinidine has a vol…
KlirensThe clearance of qu…
Genetik -
Quinine Approved DB00468
small molecule | CAS: 130-95-0

An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and h…

Kategori:
Agents that produce neuromuscular block (indirect)Agents that reduce seizure thresholdAlkaloids +57
Target Protein:
Fe(II)-protoporphyrin IXPlatelet glycoprotein IXIntermediate conductance calcium-activated potassium channel protein 4
Waktu ParuhApproximately 18 ho…
Vol. Distribusi* 1.43 ± 0.18 L/kg …
Klirens* 0.17 L/h/kg [heal…
Genetik -
biotech

Simmondsia chinensis seed is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -