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4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
2 (50.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Hasil Pencarian (4)

(R)-Propafenone DB19162
small molecule | CAS: 107381-31-7

Propafenone, (r)- is under investigation in clinical trial NCT02710669 (New Formulations of Propafenone to Treat Atrial Fibrillation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
(S)-Propafenone DB15410
small molecule | CAS: 107381-32-8

(S)-Propafenone is under investigation in clinical trial NCT02710669 (New Formulations of Propafenone to Treat Atrial Fibrillation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flecainide Approved DB01195
small molecule | CAS: 54143-55-4

Flecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone].[A186880] Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics.[A186931] It is used to prevent supraventricular and …

Kategori:
Antiarrhythmic agentsAntiarrhythmics, Class IAntiarrhythmics, Class Ic +27
Target Protein:
Sodium channel protein type 4 subunit alphaSodium channel protein type 5 subunit alphaVoltage-gated inwardly rectifying potassium channel KCNH2 +1
Waktu ParuhIn healthy subjects…
Vol. DistribusiThe average volume …
KlirensThe average clearan…
Genetik -
Propafenone Approved DB01182
small molecule | CAS: 54063-53-5

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.

Kategori:
Adrenergic AntagonistsAdrenergic beta-AntagonistsAgents causing hyperkalemia +25
Target Protein:
Sodium channel protein type 5 subunit alphaVoltage-gated inwardly rectifying potassium channel KCNH2Beta-1 adrenergic receptor +1
Waktu Paruh2-10 hours
Vol. Distribusi* 252 L
Klirens-
Genetik -