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Ciglitazone DB09201

small molecule | CAS: 74772-77-3

Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. Several analogues …

Kategori:

Blood Glucose Lowering AgentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (strength unknown) +8

Target Protein:

Peroxisome proliferator-activated receptor gamma

Waktu Paruh-

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Genetik -

Enavogliflozin DB18970

small molecule | CAS: 1415472-28-4

Enavogliflozin is under investigation in clinical trial NCT06399835 (Enavogliflozin vs. Pioglitazone on Glucose and Atherosclerosis).

Kategori:

Heterocyclic Compounds, Fused-Ring

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Leriglitazone DB15021

small molecule | CAS: 146062-44-4

Leriglitazone is under investigation in clinical trial NCT03917225 (A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich's Ataxia in Male and Female Patients).

Kategori:

Alimentary Tract and MetabolismSulfur CompoundsThiazoles +1

Target Protein:

Peroxisome proliferator-activated receptor gamma

Waktu Paruh-

Vol. Distribusi-

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Genetik -

Pioglitazone Approved DB01132

small molecule | CAS: 111025-46-8

Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference…

Kategori:

Alimentary Tract and MetabolismBlood Glucose Lowering AgentsCytochrome P-450 CYP2C8 Inhibitors +21

Target Protein:

Peroxisome proliferator-activated receptor gammaAmine oxidase [flavin-containing] B

Waktu ParuhThe mean serum half…

Vol. DistribusiThe average apparen…

KlirensThe apparent cleara…

Genetik -

Troglitazone Approved DB00197

small molecule | CAS: 97322-87-7

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].

Kategori:

Alimentary Tract and MetabolismBenzopyransBlood Glucose Lowering Agents +38

Target Protein:

Peroxisome proliferator-activated receptor gammaEstrogen-related receptor gammaSteroid hormone receptor ERR1 +6

Waktu Paruh16-34 hours

Vol. Distribusi-

Klirens-

Genetik -

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