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56

Total database: 17430
Struktur (SMILES)
44 (78.6%)
Target
37 (66.1%)
Genomik
0 (0%)
Referensi
56 (100.0%)

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Hasil Pencarian (56)

Halaman 1 / 2
small molecule | CAS: 14367-54-5

Deskripsi belum tersedia.

Target Protein:
Thermolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Primary amine oxidase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin B
Waktu Paruh-
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Genetik -
3-Tyrosine DB03552
small molecule | CAS: 587-33-7

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +2
Target Protein:
Tyrosine 3-monooxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Tyrosine--tRNA ligase, cytoplasmic
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Vol. Distribusi-
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Genetik -
small molecule | CAS: 62561-75-5

Deskripsi belum tersedia.

Target Protein:
Aminopeptidase S
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24250-85-9

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Dipeptidyl peptidase 4Aminopeptidase SEndolysin +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 76641-05-9

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule | CAS: 64192-68-3

Deskripsi belum tersedia.

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +6
Target Protein:
Amine oxidase [copper-containing] 3Primary amine oxidasePhenylethylamine oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 128592-98-3

Deskripsi belum tersedia.

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Genetik -
biotech | CAS: 2636710-07-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
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AOD9604 DB06388
small molecule | CAS: 221231-10-3

AOD9604 is a synthetic analogue of the lipolytic domain of human growth hormone, being investigated for the treatment of obesity.

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +8
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Aspartame DB00168
small molecule | CAS: 22839-47-0

Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.

Kategori:
Amino Acids, Peptides, and ProteinsCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +13
Target Protein:
Taste receptor type 1 member 3Taste receptor type 1 member 2Transient receptor potential cation channel subfamily V member 1
Waktu ParuhAt room temperature…
Vol. Distribusi-
Klirens-
Genetik -
Biphenylalanine DB04639
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1Envelope glycoprotein gp160
Waktu Paruh-
Vol. Distribusi-
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Camoteskimab DB18876
biotech | CAS: 2492472-82-7

Camoteskimab is under investigation in clinical trial NCT06436183 (A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis).

Waktu Paruh-
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D-Phenylalanine DB02556
small molecule | CAS: 673-06-3

An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]

Target Protein:
Kynurenine--oxoglutarate transaminase 1Corticoliberin
Waktu Paruh-
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D-Tyrosine DB03839
small molecule | CAS: 556-02-5

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.

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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase A1
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Genetik -
biotech | CAS: 2382896-04-8

Domofenogene zalfaparvovec, formerly known as BMN-307, is an investigational AAV5-phenylalanine hydroxylase (PAH) gene therapy developed by BioMarin Pharmaceutical.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
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Genetik -
EB05 DB16477
biotech | CAS: 2641646-59-3

EB05, in combination with standard of care (SOC), is being investigated in clinical trial NCT04401475 to evaluate its safety and efficacy in adult hospitalized patients with COVID-19 and ARDS.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Felypressin DB00093
biotech | CAS: 56-59-7

A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less tha…

Kategori:
Amino Acids, Peptides, and ProteinsCardiovascular AgentsHormones +12
Target Protein:
Vasopressin V1a receptor
Waktu Paruh-
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Fluorodopa (18F) Approved DB13848
small molecule | CAS: 92812-82-3

Fluorodopa F 18 is a fluorinated analog of [levodopa] used as a diagnostic agent for positron emission tomography (PET) in the evaluation of Parkinsonian syndromes.[L12849] Fluorodopa F 18 PET is used adjunctly with other diagnostic investigations and serves …

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +8
Waktu ParuhThe plasma half-lif…
Vol. Distribusi-
KlirensThe agent is cleare…
Genetik -
HMI-103 DB17684
biotech

HMI-102 is an investigational gene therapy designed to encode the phenylalanine-4-hydroxylase (PAH) gene, mutated in people with phenylketonuria.

Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase A1
Waktu Paruh-
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Levodopa Approved DB01235
small molecule | CAS: 59-92-7

Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administer…

Kategori:
AminesAmino AcidsAmino Acids, Aromatic +21
Target Protein:
D(1A) dopamine receptorD(1B) dopamine receptorD(2) dopamine receptor +2
Waktu Paruh2.3 hours for orall…
Vol. Distribusi168L for orally inh…
KlirensIntravenously admin…
Genetik -
Levothyroxine Approved DB00451
small molecule | CAS: 51-48-9

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland.[F4633] Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition w…

Kategori:
Agents used to treat hypothyroidismAmino AcidsAmino Acids, Aromatic +16
Target Protein:
Integrin alpha-VIntegrin beta-3Thyroid hormone receptor alpha +1
Waktu ParuhT<sub>4</sub> half-…
Vol. Distribusi-
Klirens-
Genetik -
Liothyronine Approved DB00279
small molecule | CAS: 6893-02-3

Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.[T457…

Kategori:
Agents used to treat hypothyroidismDrugs that are Mainly Renally ExcretedHormones +12
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor betaProliferating cell nuclear antigen
Waktu ParuhThe half-life of li…
Vol. DistribusiThe reported volume…
KlirensThere are no report…
Genetik -
Lumacaftor Approved DB09280
small molecule | CAS: 936727-05-8

Lumacaftor is a drug used in combination with [DB08820] as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several di…

Kategori:
AminesCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2B6 Inducers (strength unknown) +21
Target Protein:
Cystic fibrosis transmembrane conductance regulator
Waktu ParuhThe half-life of lu…
Vol. DistribusiFollowing oral admi…
KlirensThe typical apparen…
Genetik -
Melphalan Approved DB01042
small molecule | CAS: 148-82-3

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent.[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of…

Kategori:
Alkylating ActivityAlkylating DrugsAmino Acids +17
Target Protein:
DNA
Waktu ParuhIn patients given a…
Vol. DistribusiThe volume of distr…
KlirensAverage total body …
Genetik -
small molecule | CAS: 2577-90-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
ProthrombinFimbrial protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 856680-67-6

N-(carboxycarbonyl)-D-phenylalanine is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. It targets the protein hypoxia-inducible factor …

Target Protein:
Hypoxia-inducible factor 1-alpha inhibitor
Waktu Paruh-
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Genetik -
small molecule | CAS: 949-45-1

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase A1N-carbamoyl-D-amino acid hydrolase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Aminopeptidase N
Waktu Paruh-
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Genetik -
small molecule | CAS: 133397-81-6

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
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NGGT-002 DB17881
biotech

NGGT-002 is a recombinant adeno-associated virus serotype 8 vector encoding human phenylalanine hydroxylase (PAH).

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Genetik -
small molecule | CAS: 104504-45-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Tyrosine-protein phosphatase non-receptor type 1Tyrosine--tRNA ligase, cytoplasmic
Waktu Paruh-
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Genetik -
small molecule | CAS: 76410-58-7

p-Boronophenylalanine is under investigation in clinical trial NCT00039572 (Boron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the Brain).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Bacterial leucyl aminopeptidase
Waktu Paruh-
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Genetik -
Pegvaliase Approved DB12839
biotech | CAS: 1585984-95-7

Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid [A33284]. Both the U.S. Food and Drug Administration and European Medicines Agency approve…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAmmonia-Lyases +7
Target Protein:
Phenylalanine-4-hydroxylase
Waktu ParuhFollowing once-dail…
Vol. DistribusiThe mean ± SD (rang…
KlirensAt steady state fol…
Genetik -
Phelimin DB18332
small molecule

Phelemin (PHE-MIP) is a methacrylic acid-based copolymer purified to bind to L-phenylalanine and L-phenylalanine-containing peptides.[L48151] It is under investigation for the treatment of hyperphenylalaninemia.

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Phenylalanine Approved DB00120
small molecule | CAS: 63-91-2

Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +7
Target Protein:
Tyrosine 3-monooxygenaseTyrosine aminotransferaseLarge neutral amino acids transporter small subunit 2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Alpha-lytic protease
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase A1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 5241-58-7

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Substance-P receptorGenome polyproteinGenome polyprotein +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 52735-71-4

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 7060-39-1

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 2395839-91-3

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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