Hasil Pencarian (2)
small molecule | CAS: 1194506-26-7
Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathwa…
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates
+10
Target Protein:
Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3
Waktu ParuhThe fruquintinib's …
Vol. DistribusiThe mean (SD) appar…
KlirensThe apparent cleara…
Genetik
-
small molecule | CAS: 444731-52-6
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Kategori:
AmidesAngiogenesis InhibitorsAntineoplastic Agents
+36
Target Protein:
Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3
+7
Gen Terkait:
UGT1A1
HCP5
Waktu Paruh35 hours. Oral abso…
Vol. DistribusiVd steady state, IV…
KlirensCL, cancer patient,…
Genetik
2 Varian