Hasil Pencarian (2)
small molecule | CAS: 1492952-76-7
Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995]…
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors
+26
Target Protein:
Tyrosine-protein kinase ABL1
Waktu ParuhThe terminal elimin…
Vol. DistribusiAt steady-state, th…
KlirensThe total apparent …
Genetik
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small molecule | CAS: 641571-10-0
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic …
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors
+39
Target Protein:
Tyrosine-protein kinase ABL1Mast/stem cell growth factor receptor Kit
Gen Terkait:
UGT1A1
Waktu Paruh15 hours
Vol. Distribusi-
Klirens-
Genetik
1 Varian