Hasil Filter

3

Total database: 17430
Struktur (SMILES)
3 (100.0%)
Target
3 (100.0%)
Genomik
1 (33.3%)
Referensi
3 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Diltiazem Approved DB00343
small molecule | CAS: 42399-41-7

Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it prim…

Kategori:
Agents causing hyperkalemiaAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAntiarrhythmic agents +44
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent calcium channel gamma-1 subunit
Gen Terkait:
ADRB1
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe apparent volume…
KlirensFollowing a single …
Genetik 1 Varian
Isradipine Approved DB00270
small molecule | CAS: 75695-93-1

Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +25
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent L-type calcium channel subunit beta-2 +4
Waktu Paruh8 hours
Vol. Distribusi-
Klirens-
Genetik -
Nifedipine Approved DB01115
small molecule | CAS: 21829-25-4

Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridin…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +57
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent L-type calcium channel subunit alpha-1DVoltage-dependent L-type calcium channel subunit beta-2 +5
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe steady state vo…
KlirensThe total body clea…
Genetik -