Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and retention of intestinal-homing lymphocytes.[A244564, …

Natalizumab is a recombinant humanized IgG4? monoclonal antibody that binds to ?4-integrin.[L48041] While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal …

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte ?4?7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease.[L48216] ?4?7 integrin facil…