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4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
3 (75.0%)
Genomik
1 (25.0%)
Referensi
4 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Adrafinil DB08925
small molecule | CAS: 63547-13-7

Adrafinil is a mild central nervous system stimulating drug typically employed to relieve excessive sleepiness and inattention in geriatric patients. It is also been used off-label to prevent fatigue or falling asleep for extended periods of time. Adrafinil d…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Armodafinil Approved DB06413
small molecule | CAS: 112111-43-0

Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD)…

Kategori:
Benzene DerivativesBenzhydryl CompoundsCentral Nervous System Agents +21
Target Protein:
Alpha-1D adrenergic receptorSodium-dependent dopamine transporter
Waktu ParuhTerminal half-life …
Vol. DistribusiApparent volume of …
KlirensThe oral clearance …
Genetik -
Modafinil Approved DB00745
small molecule | CAS: 68693-11-8

Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, w…

Kategori:
Benzene DerivativesBenzhydryl CompoundsCentral Nervous System Agents +35
Target Protein:
Sodium-dependent dopamine transporterAlpha-1B adrenergic receptor
Gen Terkait:
COMT COMT
Waktu Paruh23-215 hours
Vol. Distribusi* 0.9 L/kg
Klirens-
Genetik 2 Varian
Pitolisant Approved DB11642
small molecule | CAS: 362665-56-3

Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy.[L8063] Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleep…

Kategori:
Cytochrome P-450 CYP1A2 InducersCytochrome P-450 CYP1A2 Inducers (strength unknown)Cytochrome P-450 CYP2B6 Inducers +25
Target Protein:
Histamine H3 receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhPitolisant has a pl…
Vol. DistribusiFollowing single an…
KlirensThe apparent oral c…
Genetik -