Hasil Filter

6

Total database: 17430
Struktur (SMILES)
6 (100.0%)
Target
5 (83.3%)
Genomik
0 (0%)
Referensi
6 (100.0%)

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Hasil Pencarian (6)

Delorazepam DB01511
small molecule | CAS: 2894-67-9

Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. It may have adverse effects such as drowsiness, and cognitive impairments such as short term memory i…

Kategori:
AnticonvulsantsBenzazepinesBenzodiazepines and benzodiazepine derivatives +4
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhVery long eliminati…
Vol. Distribusi140 L/kg apparent v…
KlirensStill detectable 72…
Genetik -
Etifoxine DB08986
small molecule | CAS: 21715-46-8

Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiaze…

Kategori:
Anti-Anxiety AgentsCentral Nervous System AgentsCentral Nervous System Depressants +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Lorazepam Approved DB00186
small molecule | CAS: 846-49-1

Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approv…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsAntiemetics +21
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhWhen administered p…
Vol. DistribusiThe reported volume…
Klirens_In vivo_ studies w…
Genetik -
Lormetazepam Approved DB13872
small molecule | CAS: 848-75-9

Lormatazepam is an orally available benzodiazepine used in the UK for the treatment of short-term insomnia [L927]. It is marketed by Auden Mckenzie (Pharma Division) in 0.5 and 1 mg tablet formulations.

Kategori:
BenzazepinesBenzodiazepines and benzodiazepine derivativesBenzodiazepinones +6
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe terminal phase …
Vol. Distribusi-
Klirens-
Genetik -
Naloxone Approved DB01183
small molecule | CAS: 465-65-6

Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide.[A234594] More specifically, naloxone has a high …

Kategori:
Alimentary Tract and MetabolismAlkaloidsAnalgesics +27
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +4
Waktu ParuhThe mean half life …
Vol. DistribusiThe volume of distr…
KlirensThe clearance of na…
Genetik -
Oxazepam Approved DB00842
small molecule | CAS: 604-75-1

Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on p…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +16
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -