Hasil Filter

6

Total database: 17430
Struktur (SMILES)
6 (100.0%)
Target
6 (100.0%)
Genomik
1 (16.7%)
Referensi
6 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (6)

Aminosalicylic acid Approved DB00233
small molecule | CAS: 65-49-6

An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.

Kategori:
Acids, CarbocyclicAminobenzoatesAminosalicylic Acid and Derivatives +14
Target Protein:
Prostaglandin G/H synthase 1Dihydrofolate reductaseProstaglandin G/H synthase 2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bedaquiline Approved DB08903
small molecule | CAS: 843663-66-1

Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity.[A261866] Althoug…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiinfectives for Systemic Use +10
Target Protein:
ATP synthase subunit c
Waktu ParuhThe mean terminal e…
Vol. DistribusiThe volume of distr…
KlirensBedaquiline has a l…
Genetik -
Clofazimine Approved DB00845
small molecule | CAS: 2030-63-9

Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye th…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory Agents +23
Target Protein:
Peroxisome proliferator-activated receptor gammaPotassium voltage-gated channel subfamily A member 3
Waktu ParuhThe mean eliminatio…
Vol. DistribusiClofazimine is high…
Klirens-
Genetik -
Ethambutol Approved DB00330
small molecule | CAS: 74-55-5

Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed ou…

Kategori:
AminesAnti-Bacterial AgentsAnti-Infective Agents +23
Target Protein:
Probable arabinosyltransferase CProbable arabinosyltransferase BProbable arabinosyltransferase A
Waktu ParuhEthambutol has a ha…
Vol. DistribusiPatients coinfected…
KlirensPatients coinfected…
Genetik -
Isoniazid Approved DB00951
small molecule | CAS: 54-85-3

Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.

Kategori:
Agents Causing Muscle ToxicityAgents that reduce seizure thresholdAnti-Bacterial Agents +39
Target Protein:
Catalase-peroxidaseEnoyl-[acyl-carrier-protein] reductase [NADH]Cytochrome P450 2C8 +4
Gen Terkait:
CYP2E1
Waktu ParuhFast acetylators: 0…
Vol. Distribusi-
Klirens-
Genetik 1 Varian
Pyridoxine Approved DB00165
small molecule | CAS: 65-23-6

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of man…

Kategori:
Alimentary Tract and MetabolismAnalogs/DerivativesAntiinfectives for Systemic Use +10
Target Protein:
Aromatic-L-amino-acid decarboxylasePyridoxal kinase
Waktu ParuhThe total adult bod…
Vol. DistribusiPyridoxine main act…
Klirens-
Genetik -