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Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
4 (100.0%)
Genomik
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Referensi
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Status Regulasi

Hasil Pencarian (4)

Irbesartan Approved DB01029
small molecule | CAS: 138402-11-6

Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.[L7456,L7459] It can also be used as part of a combination product with [hydrochlorothiazide] for patients not well controlled or not expected to be we…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing hyperkalemiaAngiotensin 2 Receptor Blocker +24
Target Protein:
Type-1 angiotensin II receptorTranscription factor Jun
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensTotal plasma cleara…
Genetik -
Olmesartan Approved DB00275
small molecule | CAS: 144689-24-7

Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiote…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing hyperkalemiaAngiotensin 2 Receptor Blocker +15
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhThe mean plasma olm…
Vol. Distribusi17 L[L5566]
KlirensTotal plasma cleara…
Genetik -
Sparsentan Approved DB12548
small molecule | CAS: 254740-64-2

Sparsentan is a dual antagonist of the endothelin type A receptor (ET<sub>A</sub>R) and the angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>R) with a similar affinity for both (9.3 nM for ET<sub>A</sub>R and 0.8 nM for AT<sub>1</sub>R).[A257330,L45300]…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAmidesAngiotensin 2 Receptor Blocker +30
Target Protein:
Endothelin-1 receptorType-1 angiotensin II receptorType-2 angiotensin II receptor
Waktu ParuhSparsentan has an e…
Vol. DistribusiAt the approved rec…
KlirensSparsentan has a ti…
Genetik -
Valsartan Approved DB00177
small molecule | CAS: 137862-53-4

Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [olmesartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiote…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +22
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhAfter intravenous (…
Vol. DistribusiThe steady-state vo…
KlirensFollowing intraveno…
Genetik -