Hasil Filter

7

Total database: 17430
Struktur (SMILES)
7 (100.0%)
Target
6 (85.7%)
Genomik
5 (71.4%)
Referensi
7 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (7)

Clomipramine Approved DB01242
small molecule | CAS: 303-49-1

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-de…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +45
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2B +3
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhFollowing oral admi…
Vol. Distribusi~ 17 L/kg (range: 9…
Klirens-
Genetik 9 Varian
Desipramine Approved DB01151
small molecule | CAS: 50-47-5

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, de…

Kategori:
Adrenergic AgentsAdrenergic Uptake InhibitorsAgents producing tachycardia +52
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A +14
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +4
Waktu Paruh7-60+ hours; 70% el…
Vol. Distribusi-
Klirens-
Genetik 7 Varian
Dimetacrine DB08996
small molecule | CAS: 4757-55-5

Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in Europe for the treatment of depression. D…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +9
Target Protein:
Acetylcholinesterase
Waktu ParuhApproximately 10 ho…
Vol. DistribusiThe highest concent…
Klirens-
Genetik -
Doxepin Approved DB01142
small molecule | CAS: 1668-19-5

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties.[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) race…

Kategori:
Acid ReducersAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +55
Target Protein:
Histamine H1 receptorHistamine H2 receptorSodium-dependent noradrenaline transporter +16
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +5
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean apparent v…
KlirensThe mean total appa…
Genetik 8 Varian
Imipramine Approved DB00458
small molecule | CAS: 50-49-7

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individ…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +70
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A +21
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhImipramine has a me…
Vol. DistribusiImipramine has a hi…
KlirensImipramine has a me…
Genetik 9 Varian
small molecule | CAS: 6829-98-7

Deskripsi belum tersedia.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trimipramine Approved DB00726
small molecule | CAS: 739-71-9

Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +44
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporterSodium-dependent dopamine transporter +15
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +5
Waktu Paruh11-18 hrs
Vol. Distribusi-
Klirens-
Genetik 8 Varian