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Total database: 17430
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Hasil Pencarian (4)

Ganciclovir Approved DB01004
small molecule | CAS: 82410-32-0

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

Kategori:
Agents Causing Muscle ToxicityAgents that reduce seizure thresholdAnti-Infective Agents +23
Target Protein:
DNA polymerase catalytic subunitDNAThymidine kinase
Waktu Paruh2.5 to 3.6 hours (m…
Vol. Distribusi* 0.74 ± 0.15 L/kg
Klirens* 128 +/- 63 mL/min…
Genetik -
Maribavir Approved DB06234
small molecule | CAS: 176161-24-3

Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation.[L39322] Most standard CMV therapies, such as [ganciclovir] or [foscarnet], target CMV DNA polymerase - while gene…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +14
Target Protein:
Serine/threonine protein kinase UL97
Waktu ParuhIn post-transplant …
Vol. DistribusiThe mean apparent s…
KlirensIn post-transplant …
Genetik -
Valganciclovir Approved DB01610
small molecule | CAS: 175865-60-8

Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converte…

Kategori:
Agents that reduce seizure thresholdAnti-Infective AgentsAntiinfectives for Systemic Use +13
Target Protein:
DNA polymerase catalytic subunitDNA
Waktu ParuhApproximately 4.08 …
Vol. Distribusi* 0.703 ± 0.134 L/kg
Klirens* 3.07+/- 0.64 mL/m…
Genetik -
small molecule | CAS: 897937-73-4

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