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4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
3 (75.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Hasil Pencarian (4)

Benfluorex DB09022
small molecule | CAS: 23602-78-0

Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended withdrawing all benfluorex containing…

Kategori:
Alimentary Tract and MetabolismAminesAnti-Obesity Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dexfenfluramine Approved DB01191
small molecule | CAS: 3239-44-9

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the ca…

Kategori:
Alimentary Tract and MetabolismAminesAntidepressive Agents +17
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2C
Waktu Paruh17-20 hours
Vol. Distribusi-
Klirens-
Genetik -
Fenfluramine Approved DB00574
small molecule | CAS: 458-24-2

Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with diseas…

Kategori:
Alimentary Tract and MetabolismAminesAnticonvulsants +27
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 2C +4
Waktu ParuhFenfluramine has an…
Vol. DistribusiFenfluramine has an…
KlirensFenfluramine has a …
Genetik -
Phentermine Approved DB00191
small molecule | CAS: 122-09-8

Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phe…

Kategori:
Adrenergic AgentsAgents producing tachycardiaAgents that produce hypertension +22
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterSodium-dependent dopamine transporter +3
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe reported volume…
KlirensThe reported cleara…
Genetik -