Hasil Pencarian (2)
small molecule | CAS: 1108743-60-7
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positi…
Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+17
Target Protein:
ALK tyrosine kinase receptorHigh affinity nerve growth factor receptorNT-3 growth factor receptor
+4
Waktu ParuhEntrectinib has a h…
Vol. DistribusiEntrectinib has an …
KlirensThe apparent cleara…
Genetik
-
small molecule | CAS: 1802220-02-5
Repotrectinib is a next-generation tyrosine kinase inhibitor (TKI) specifically designed to address resistance in the treatment of non-small cell lung cancer (NSCLC), specifically due to mutations in the ROS1 gene.[A262056] ROS1 mutations are one of the defin…
Kategori:
BCRP/ABCG2 InhibitorsCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2B6 Inducers (strength unknown)
+28
Target Protein:
Proto-oncogene tyrosine-protein kinase ROSHigh affinity nerve growth factor receptorBDNF/NT-3 growth factors receptor
+1
Waktu ParuhThe repotrectinib m…
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik
-