Hasil Pencarian (2)
small molecule | CAS: 1446502-11-9
Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of…
Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+62
Target Protein:
Isocitrate dehydrogenase [NADP] cytoplasmicIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIsocitrate dehydrogenase [NAD] subunit beta, mitochondrial
+2
Waktu ParuhEnasidenib has a te…
Vol. DistribusiThe mean volume of …
KlirensEnasidenib has a me…
Genetik
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small molecule | CAS: 1644545-52-7
Vorasidenib is a first-in-class dual isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2) inhibitor.[A264209] It works by suppressing the levels of D-2-hydroxyglutarate (2-HG), an oncometabolite produced by mutant IDH1 and IDH2 isoforms.[L5…
Kategori:
AminesBCRP/ABCG2 InhibitorsCytochrome P-450 CYP1A2 Substrates
+26
Target Protein:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialIsocitrate dehydrogenase [NAD] subunit beta, mitochondrialIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
+2
Waktu ParuhThe mean (CV%) stea…
Vol. DistribusiThe mean (CV%) volu…
KlirensThe mean (CV%) stea…
Genetik
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