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Total database: 17430
Struktur (SMILES)
4 (80.0%)
Target
4 (80.0%)
Genomik
2 (40.0%)
Referensi
5 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (5)

Cidoxepin DB14750
small molecule | CAS: 3607-18-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desipramine Approved DB01151
small molecule | CAS: 50-47-5

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, de…

Kategori:
Adrenergic AgentsAdrenergic Uptake InhibitorsAgents producing tachycardia +52
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A +14
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +4
Waktu Paruh7-60+ hours; 70% el…
Vol. Distribusi-
Klirens-
Genetik 7 Varian
Doxepin Approved DB01142
small molecule | CAS: 1668-19-5

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties.[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) race…

Kategori:
Acid ReducersAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +55
Target Protein:
Histamine H1 receptorHistamine H2 receptorSodium-dependent noradrenaline transporter +16
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +5
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean apparent v…
KlirensThe mean total appa…
Genetik 8 Varian
Olopatadine Approved DB00768
small molecule | CAS: 113806-05-6

Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions. It is a structural analog of [doxepin], which has a minimal anti-allergic activity.[L6790] Olopatadine works by blocking…

Kategori:
Anti-Allergic AgentsAnti-Inflammatory AgentsAntiallergic Agents, Excl. Corticosteroids +23
Target Protein:
Histamine H1 receptorHistamine H2 receptorHistamine H3 receptor +5
Waktu ParuhFollowing ocular ad…
Vol. DistribusiIn an open-label st…
KlirensIn an open-label st…
Genetik -
SO-101 DB05345
small molecule

SO-101(Silenor) is a low-dose oral tablet formulation of doxepin hydrochloride that is patent protected for its use in insomnia. Doxepin has been prescribed for more than 40 years for the treatment of depression and anxiety at dosages typically ranging from 7…

Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -