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4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
3 (75.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Acamprosate Approved DB00659
small molecule | CAS: 77337-76-9

Alcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and economic consequences resulting from accidents, violence, incarceration, decreased productivity, and increased healthcare spending.[A229073] Acamprosate…

Kategori:
Alcohol DeterrentsCentral Nervous System AgentsDrugs Used in Addictive Disorders +8
Target Protein:
Glutamate (NMDA) receptorMetabotropic glutamate receptor 5Gamma-aminobutyric acid type B receptor subunit 1
Waktu ParuhIn pharmacokinetic …
Vol. DistribusiAt steady state con…
KlirensSevere renal insuff…
Genetik -
Calcium carbimide Approved DB09116
small molecule | CAS: 156-62-7

Calcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic product acetaldehy…

Kategori:
CarbodiimidesCyanidesDrugs Used in Addictive Disorders +4
Target Protein:
Aldehyde dehydrogenase family 3 member B2Aldehyde dehydrogenase, mitochondrialAldehyde dehydrogenase X, mitochondrial +1
Waktu ParuhCalcium carbimide i…
Vol. DistribusiThe apparent volume…
KlirensAfter intravenous a…
Genetik -
Disulfiram Approved DB00822
small molecule | CAS: 97-77-8

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde con…

Kategori:
Acetyl Aldehyde Dehydrogenase InhibitorsAcids, AcyclicAgents that reduce seizure threshold +26
Target Protein:
Dopamine beta-hydroxylaseAldehyde dehydrogenase family 3 member A2Aldehyde dehydrogenase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ditiocarb DB02520
small molecule | CAS: 147-84-2

A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.

Kategori:
Acids, AcyclicAdjuvants, ImmunologicAnti-Infective Agents +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -