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12

Total database: 17430
Struktur (SMILES)
12 (100.0%)
Target
11 (91.7%)
Genomik
0 (0%)
Referensi
12 (100.0%)

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Hasil Pencarian (12)

Camazepam DB01489
small molecule | CAS: 36104-80-0

Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzod…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +5
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorazepic acid Approved DB00628
small molecule | CAS: 23887-31-2

Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam)…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsBenzazepines +15
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe serum half-life…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Delorazepam DB01511
small molecule | CAS: 2894-67-9

Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. It may have adverse effects such as drowsiness, and cognitive impairments such as short term memory i…

Kategori:
AnticonvulsantsBenzazepinesBenzodiazepines and benzodiazepine derivatives +4
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhVery long eliminati…
Vol. Distribusi140 L/kg apparent v…
KlirensStill detectable 72…
Genetik -
Diazepam Approved DB00829
small molecule | CAS: 439-14-5

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disor…

Kategori:
Adjuvants, AnesthesiaAnestheticsAnesthetics, General +40
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhDiazepam has a biph…
Vol. DistribusiIn young healthy ma…
KlirensThe clearance of di…
Genetik -
Estazolam Approved DB01215
small molecule | CAS: 29975-16-4

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.

Kategori:
Anti-Anxiety AgentsAnticonvulsantsBenzazepines +20
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe range of estima…
Vol. Distribusi-
Klirens-
Genetik -
Fludiazepam DB01567
small molecule | CAS: 3900-31-0

Fludiazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a scheduled drug in the U.S., but is approved for use in Japan.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +11
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Translocator proteinGamma-aminobutyric acid receptor subunit alpha-2 +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Flunitrazepam Approved DB01544
small molecule | CAS: 1622-62-4

Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Gov…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +28
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh18-26 hours
Vol. Distribusi-
Klirens-
Genetik -
Halazepam Approved DB00801
small molecule | CAS: 23092-17-3

Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam.[A1212] This drug is no longer marketed in the Unite…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +7
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naloxone Approved DB01183
small molecule | CAS: 465-65-6

Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide.[A234594] More specifically, naloxone has a high …

Kategori:
Alimentary Tract and MetabolismAlkaloidsAnalgesics +27
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +4
Waktu ParuhThe mean half life …
Vol. DistribusiThe volume of distr…
KlirensThe clearance of na…
Genetik -
Nordazepam DB14028
small molecule | CAS: 1088-11-5

An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +15
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Oxazepam Approved DB00842
small molecule | CAS: 604-75-1

Oxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on p…

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +16
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Zolazepam DB11555
small molecule | CAS: 31352-82-6

Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the ?2 adrenoceptor agonist xylazine. It is around four times the potency of diazepa…

Kategori:
Anti-Anxiety AgentsCentral Nervous System AgentsCentral Nervous System Depressants +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -