Hasil Pencarian (2)
small molecule | CAS: 1195765-45-7
Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation.[L41955] It was also used for metastatic non-small cell …
Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+64
Target Protein:
Serine/threonine-protein kinase B-rafRAF proto-oncogene serine/threonine-protein kinaseSerine/threonine-protein kinase SIK1
+2
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of da…
Genetik
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small molecule | CAS: 871700-17-3
Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma.[A258298] It was later approved by Health Can…
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C8 Inhibitors
+20
Target Protein:
Dual specificity mitogen-activated protein kinase kinase 1Dual specificity mitogen-activated protein kinase kinase 2
Waktu ParuhThe estimated elimi…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik
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