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Total database: 17430
Struktur (SMILES)
3 (75.0%)
Target
4 (100.0%)
Genomik
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Referensi
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Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Colchiceine Approved DB15534
small molecule | CAS: 477-27-0

Colchiceine is one of several metabolites of the anti-gout medication [colchicine].[A192714]

Kategori:
AlkaloidsColchicine DerivativesTubulin Inhibiting Agent
Target Protein:
Tubulin beta chainTubulin alpha-1A chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Colchicine Approved DB01394
small molecule | CAS: 64-86-8

Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus."[A183611] Its use was first approved by the FDA in 1961.[L8192] Colchicine is used in the treatment of gout flares and Familia…

Kategori:
Agents Causing Muscle ToxicityAlkaloidsAntigout Preparations +23
Target Protein:
Tubulin beta chain
Waktu ParuhAfter several doses…
Vol. DistribusiThe mean apparent v…
KlirensIn one pharmacokine…
Genetik -
Opium Approved DB11130
small molecule | CAS: 8008-60-4

Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it wa…

Kategori:
Alimentary Tract and MetabolismAnalgesicsAntidiarrheals +25
Target Protein:
Delta-type opioid receptorKappa-type opioid receptorMu-type opioid receptor
Waktu ParuhThe half-life of op…
Vol. DistribusiOpium presents a la…
Klirens-
Genetik -
small molecule | CAS: 602-41-5

Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of _Superba gloriosa_. It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convul…

Kategori:
AlkaloidsCentral Nervous System DepressantsMuscle Relaxants +2
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Glycine receptor subunit alpha-2 +6
Waktu ParuhApproximately 7.7h …
Vol. DistribusiThe apparent volume…
KlirensPrimarily extrarena…
Genetik -