Hasil Filter

5

Total database: 17430
Struktur (SMILES)
5 (100.0%)
Target
3 (60.0%)
Genomik
0 (0%)
Referensi
5 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (5)

small molecule | CAS: 24818-79-9

Deskripsi belum tersedia.

Kategori:
Agents Causing Muscle ToxicityFibric AcidsLipid Modifying Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clofibrate Approved DB00636
small molecule | CAS: 637-07-0

A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +25
Target Protein:
Peroxisome proliferator-activated receptor alphaLipoprotein lipase
Waktu ParuhHalf-life in normal…
Vol. Distribusi-
Klirens-
Genetik -
Etofibrate DB08983
small molecule | CAS: 31637-97-5

Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fenofibrate Approved DB01039
small molecule | CAS: 49562-28-9

Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil].[A185954] Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 Decemb…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +39
Target Protein:
Peroxisome proliferator-activated receptor alphaNuclear receptor subfamily 1 group I member 2Matrix metalloproteinase-25
Waktu ParuhFenofibric acid, th…
Vol. DistribusiThe volume of distr…
KlirensThe oral clearance …
Genetik -
Gemfibrozil Approved DB01241
small molecule | CAS: 25812-30-0

Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exer…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +53
Target Protein:
Peroxisome proliferator-activated receptor alphaLipoprotein lipaseSolute carrier organic anion transporter family member 1B1 +3
Waktu ParuhGemfibrozil has a p…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ge…
Genetik -