Hasil Pencarian (2)
small molecule | CAS: 1032900-25-6
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC …
Kategori:
Anaplastic lymphoma kinase (ALK) inhibitorsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+25
Target Protein:
ALK tyrosine kinase receptor
Waktu ParuhThe terminal half l…
Vol. DistribusiThe apparent volume…
KlirensThe geometric mean …
Genetik
-
small molecule | CAS: 1108743-60-7
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positi…
Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+17
Target Protein:
ALK tyrosine kinase receptorHigh affinity nerve growth factor receptorNT-3 growth factor receptor
+4
Waktu ParuhEntrectinib has a h…
Vol. DistribusiEntrectinib has an …
KlirensThe apparent cleara…
Genetik
-