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Total database: 17430
Struktur (SMILES)
7 (77.8%)
Target
6 (66.7%)
Genomik
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Hasil Pencarian (9)

Capecitabine Approved DB01101
small molecule | CAS: 154361-50-9

Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA sy…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +21
Target Protein:
Thymidylate synthaseDNARNA +1
Gen Terkait:
DPYD DPYD DPYD +4
Waktu ParuhThe elimination hal…
Vol. DistribusiIn colorectal cance…
KlirensIn colorectal cance…
Genetik 7 Varian
GTI-2040 DB15030
biotech | CAS: 236391-66-5

GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesOligonucleotides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Lapatinib Approved DB01259
small molecule | CAS: 231277-92-2

Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with t…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates +22
Target Protein:
Epidermal growth factor receptorEukaryotic elongation factor 2 kinaseReceptor tyrosine-protein kinase erbB-2
Gen Terkait:
HLA-DQA1 HLA-DRB1 HLA-DQB1 +1
Waktu ParuhSingle-dose termina…
Vol. Distribusi-
Klirens-
Genetik 4 Varian
Nedisertib DB16252
small molecule | CAS: 1637542-33-6

Nedisertib is under investigation in clinical trial NCT03770689 (Study of M3814 in Combination With Capecitabine and Radiotherapy in Rectal Cancer).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
DNA-dependent protein kinase catalytic subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelmastobart DB19000
biotech | CAS: 2669823-48-5

Nelmastobart is under investigation in clinical trial NCT05990543 (Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telatinib DB15393
small molecule | CAS: 332012-40-5

Telatinib is under investigation in clinical trial NCT03817411 (Telatinib in Combination With Capecitabine/ Oxaliplatin in 1st Line Gastric or GEJ Cancer).

Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrachlorodecaoxide Approved DB05389
small molecule | CAS: 92047-76-2

WF10 is a chlorite-based, immunomodulating drug is developed by Nuvo Research Inc. Certain preclinical evidence and clinical pilot data suggest that WF10 may be effective in treating certain cancers. The Corporation believes the research to-date demonstrates …

Kategori:
AnionsCompounds used in a research, industrial, or household settingElectrolytes +7
Target Protein:
E3 ubiquitin-protein transferase MAEAScavenger receptor cysteine-rich type 1 protein M130
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tucatinib Approved DB11652
small molecule | CAS: 937263-43-9

Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020.[L12951] Tucatinib is a…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +18
Target Protein:
Receptor tyrosine-protein kinase erbB-2Receptor tyrosine-protein kinase erbB-3
Waktu ParuhA pharmacokinetic s…
Vol. DistribusiThe volume of distr…
KlirensThe apparent cleara…
Genetik -
Uridine triacetate Approved DB09144
small molecule | CAS: 4105-38-8

Uridine triacetate, formerly known as vistonuridine, is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabin…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismFatty Acids +9
Waktu Paruh2 to 2.5 hours
Vol. DistribusiCirculating uridine…
Klirens-
Genetik -