Hasil Pencarian (2)
small molecule | CAS: 1492952-76-7
Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995]…
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors
+26
Target Protein:
Tyrosine-protein kinase ABL1
Waktu ParuhThe terminal elimin…
Vol. DistribusiAt steady-state, th…
KlirensThe total apparent …
Genetik
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small molecule | CAS: 380843-75-4
Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hall…
Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+22
Target Protein:
Tyrosine-protein kinase ABL1Tyrosine-protein kinase LynProto-oncogene tyrosine-protein kinase Src
+8
Waktu ParuhThe mean (SD) bosut…
Vol. DistribusiThe mean (SD) appar…
KlirensThe mean (SD) appar…
Genetik
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